EC Number | Application | Comment | Organism |
---|---|---|---|
2.3.3.13 | medicine | alpha-isopropylmalate synthase is a target for the design of new antitubercular therapeutics | Mycobacterium tuberculosis |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.3.13 | - |
Mycobacterium tuberculosis |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.3.3.13 | Y410F | mutant, insensitive to L-leucine inhibition | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.3.13 | L-leucine | feedback inhibition | Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.3.13 | acetyl-CoA + 3-methyl-2-oxobutanoate + H2O | Mycobacterium tuberculosis | - |
(2S)-2-isopropylmalate + CoA | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.3.13 | Mycobacterium tuberculosis | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.3.13 | on a nickel-NTA, a Mono-Q and a Phenyl Sepharose column | Mycobacterium tuberculosis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.3.13 | acetyl-CoA + 3-methyl-2-oxobutanoate + H2O | - |
Mycobacterium tuberculosis | (2S)-2-isopropylmalate + CoA | - |
? | |
2.3.3.13 | alpha-ketoisovaleric acid + H2O + acetyl-CoA | - |
Mycobacterium tuberculosis | ? + CoA | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.3.13 | Alpha-isopropylmalate synthase | - |
Mycobacterium tuberculosis |
2.3.3.13 | MtIPMS | - |
Mycobacterium tuberculosis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.3.3.13 | acetyl-CoA | - |
Mycobacterium tuberculosis |