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Literature summary extracted from

  • McCarty, R.M.; Somogyi, A.; Bandarian, V.
    Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase (2009), Biochemistry, 48, 2301-2303.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.3.12 expressed in Escherichia coli BL21(DE3) Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.3.12 Zn2+
-
 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.50 Escherichia coli
-
 gene queD
-
4.2.3.12 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.3.12
-
 Escherichia coli

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.2.50 7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate reaction mechanism, overview Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.50 6-pyruvoyltetrahydropterin + H2O
-
 Escherichia coli 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate
-
 ?
4.1.2.50 7,8-dihydroneopterin triphosphate + H2O
-
 Escherichia coli 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate
-
 ?
4.1.2.50 additional information 6-pyruvoyltetrahydropterin can tautomerize to sepiapterin, the hydrate of which undergoes carbon-carbon bond cleavage by an aldolase-like mechanism, followed by a tautomerization, to yield 6-carboxy-5,6,7,8-tetrahydropterin Escherichia coli ?
-
 ?
4.1.2.50 sepiapterin + H2O
-
 Escherichia coli 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate
-
 ?
4.2.3.12 6-pyruvoyltetrahydropterin
-
 Escherichia coli 6-carboxy-5,6,7,8-tetrahydropterin + ?
-
 ?
4.2.3.12 7,8-dihydroneopterin triphosphate
-
 Escherichia coli 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
 ?
4.2.3.12 sepiapterin
-
 Escherichia coli 6-carboxy-5,6,7,8-tetrahydropterin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.2.50 6-carboxy-5,6,7,8-tetrahydropterin synthase
-
 Escherichia coli
4.1.2.50 QueD
-
 Escherichia coli
4.2.3.12 6-carboxy-5,6,7,8-tetrahydropterin synthase 6-pyruvoyl-5,6,7,8-tetrahydropterin synthase homologue, gene QueD Escherichia coli

General Information

EC Number General Information Comment Organism
4.1.2.50 physiological function QueD catalyzes the conversion of 7,8-dihydroneopterin triphosphate to 6-carboxy-5,6,7,8-tetrahydropterin, CPH4. QueD can also convert 6-pyruvoyltetrahydropterin, PPH4, and sepiapterin to CPH4 Escherichia coli