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Literature summary extracted from

  • Lill, S.O.; Siegbahn, P.E.
    An autocatalytic mechanism for NiFe-hydrogenase: reduction to Ni(I) followed by oxidative addition (2009), Biochemistry, 48, 1056-1066.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.12.99.6 Ni2+
-
 Solidesulfovibrio fructosivorans

Organism

EC Number Organism UniProt Comment Textmining
1.12.99.6 Solidesulfovibrio fructosivorans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.12.99.6 H2 + oxidized acceptor heterolytic H2 cleavage, with one hydrogen ending up as a bridging hydride and one as a proton on a cysteine ligand, which has a barrier slightly too high to be compatible with measured catalytic turnover rates. Alternative mechanisms suggest heterolytic cleavage as an initial step to generate a complex with nickel in oxidation state Ni(I). In the following cycles, H2 is instead cleaved on nickel using an oxidative addition mechanism with a lower barrier Solidesulfovibrio fructosivorans H+ + reduced acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.12.99.6 NiFe-hydrogenase
-
 Solidesulfovibrio fructosivorans

Cofactor

EC Number Cofactor Comment Organism Structure
1.12.99.6 NAD+
-
 Solidesulfovibrio fructosivorans