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Literature summary extracted from

  • Hsu, A.Y.; Poon, W.W.; Shepherd, J.A.; Myles, D.C.; Clarke, C.F.
    Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis (1996), Biochemistry, 35, 9797-9806.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.64 the ubiG gene is able to restore respiration in the yeast coq3 mutant, provided ubiG is modified to contain a mitochondrial leader sequence Escherichia coli
2.1.1.222 the ubiG gene is able to restore respiration in the yeast coq3 mutant, provided ubiG is modified to contain a mitochondrial leader sequence Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.64 S-adenosyl-L-methionine + 3-demethylubiquinol-8 Escherichia coli the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3,4-dihydroxy-5-octaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-8 S-adenosyl-L-homocysteine + ubiquinol-8
-
 ?
2.1.1.222 S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol Escherichia coli the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3-(all-trans-octaprenyl)benzene-1,2-diol and 2. the methylation of 3-demethylubiquinol-8 (this reaction is classified as EC 2.1.1.64) S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.64 Escherichia coli
-
-
-
2.1.1.222 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.64 S-adenosyl-L-methionine + 3-demethylubiquinol-3 i.e. 5-((2E,6E)-farnesyl)-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone Escherichia coli S-adenosyl-L-homocysteine + ubiquinol-3
-
 ?
2.1.1.64 S-adenosyl-L-methionine + 3-demethylubiquinol-8 the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3,4-dihydroxy-5-octaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-8 Escherichia coli S-adenosyl-L-homocysteine + ubiquinol-8
-
 ?
2.1.1.222 S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol Escherichia coli S-adenosyl-L-homocysteine + 2-methoxy-6-((2E,6E)-farnesyl)phenol i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol ?
2.1.1.222 S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol
-
 Escherichia coli S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol
-
 ?
2.1.1.222 S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3-(all-trans-octaprenyl)benzene-1,2-diol and 2. the methylation of 3-demethylubiquinol-8 (this reaction is classified as EC 2.1.1.64) Escherichia coli S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.64 UbiG
-
 Escherichia coli
2.1.1.64 UbiG methyltransferase
-
 Escherichia coli
2.1.1.222 UbiG
-
 Escherichia coli
2.1.1.222 UbiG methyltransferase
-
 Escherichia coli