Literature summary extracted from

Megias, J.; Guillen, M.I.; Clerigues, V.; Rojo, A.I.; Cuadrado, A.; Castejon, M.A.; Gomar, F.; Alcaraz, M.J.
Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes (2009), Biochem. Pharmacol., 77, 1806-1813.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5.3.99.3	Prostaglandin H2	Homo sapiens	-	Prostaglandin E2	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.3.99.3	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
5.3.99.3	chondrocyte	osteoarthritic chondrocyte	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.3.99.3	Prostaglandin H2	-	Homo sapiens	Prostaglandin E2	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
5.3.99.3	microsomal prostaglandin E synthase-1	-	Homo sapiens
5.3.99.3	mPGES-1	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
5.3.99.3	Homo sapiens	0.01 mM cobalt protoporphyrin IX down-regulates mPGES-1 protein	down
5.3.99.3	Homo sapiens	100 units/ml interleukin-1beta induces the expression of COX-2 and mPGES-1 in osteoarthritic chondrocytes	up

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Release 2023.1 (January 2023)