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Literature summary extracted from

  • Matsuo, T.; Yamamoto, A.; Yamamoto, T.; Otsuki, K.; Yamazaki, N.; Kataoka, M.; Terada, H.; Shinohara, Y.
    Replacement of C305 in Heart/Muscle-Type Isozyme of Human Carnitine Palmitoyltransferase I with Aspartic Acid and Other Amino Acids (2010), Biochem. Genet., 48, 193-201.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.21 expressed in COS-7 cell Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.21 C304A reduced expression in COS-7 cell, reduced activity Homo sapiens
2.3.1.21 C304W reduced expression in COS-7 cell, reduced activity Homo sapiens
2.3.1.21 C305A 5% of wild-type activity in mitochondrial fraction, 30% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305D 73% of wild-type activity in mitochondrial fraction (COS-7 cell), 81% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305E 50% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305F about 20% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305G about 5% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305H 38% of wild-type activity in mitochondrial fraction in COS-7 cell Homo sapiens
2.3.1.21 C305I 4% of wild-type activity in mitochondrial fraction in COS-7 cell Homo sapiens
2.3.1.21 C305K about 25% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305L about 20% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305M about 20% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305N about 10% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305P about 20% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305Q about 30% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305R about 20% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305S about 20% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305T about 10% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305V about 25% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305W 8% of wild-type activity in mitochondrial fraction, 30% of wild-type expression in COS-7 cell Homo sapiens
2.3.1.21 C305Y about 20% of wild-type expression in COS-7 cell Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 heart
-
 Homo sapiens
-
2.3.1.21 liver
-
 Homo sapiens
-
2.3.1.21 muscle
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.21 0.00227
-
 mitochondrial fraction, wild-type protein expressed in COS-7 cell Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 L-carnitine + palmitoyl-CoA
-
 Homo sapiens L-palmitoylcarnitine + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.21 carnitine palmitoyltransferase I heart/muscle-type isoenzyme Homo sapiens
2.3.1.21 carnitine palmitoyltransferase I liver-type isoenzyme Homo sapiens