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Literature summary extracted from

  • Weyrich, A.; Tang, X.; Xu, G.; Schrattenholz, A.; Hunzinger, C.; Hennig, W.
    Mammalian DNMTs in the male germ line DNA of Drosophila (2008), Biochem. Cell Biol., 86, 380-385.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.37 overexpression of Dnmt3a and Dnmt3b Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.37 additional information enzyme overexpression does not cause an altered phenotype Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.37 nucleus
-
 Drosophila melanogaster 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.37 DNA + S-adenosyl-L-methionine Drosophila melanogaster the enzyme has distinct target sequences but no preferred methylation sites of promoters or other regulatory elements DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.37 Drosophila melanogaster
-
 isozymes Dnmt3a and Dnmt3b
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.37 germ cell male Drosophila melanogaster
-
2.1.1.37 spermatid
-
 Drosophila melanogaster
-
2.1.1.37 spermatocyte primary Drosophila melanogaster
-
2.1.1.37 testis
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.37 DNA + S-adenosyl-L-methionine the enzyme has distinct target sequences but no preferred methylation sites of promoters or other regulatory elements Drosophila melanogaster DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.37 DNA + S-adenosyl-L-methionine substrate is genomic DNA of Drosophila melanogaster Drosophila melanogaster DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.37 DNA (cytosine-5)-methyltransferase 3A
-
 Drosophila melanogaster
2.1.1.37 DNA (cytosine-5)-methyltransferase 3B
-
 Drosophila melanogaster
2.1.1.37 Dnmt3a
-
 Drosophila melanogaster
2.1.1.37 DNMT3B
-
 Drosophila melanogaster

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.37 37
-
 assay at Drosophila melanogaster

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.37 7.5
-
 assay at Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.37 S-adenosyl-L-methionine
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.1.1.37 physiological function the DNA methylation by the enzyme has no regulatory function for gene expression in Drosophile melnogaster Drosophila melanogaster