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Literature summary extracted from

  • Sachan, D.S.; Hoppel, C.L.
    Carnitine biosynthesis. Hydroxylation of N6-trimethyl-lysine to 3-hydroxy-N6-trimethyl-lysine (1980), Biochem. J., 188, 529-534.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.8 Mg2+
-
 Rattus norvegicus
1.14.11.8 Mn2+
-
 Rattus norvegicus
1.14.11.8 Zn2+
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.11.8 1.6
-
 trimethyllysine
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.8 mitochondrion
-
 Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.8 Ca2+ stimulation Rattus norvegicus
1.14.11.8 FeSO4 required Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.8 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.8 kidney cortex (67%), medulla (33%) Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.8 N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 N6,N6, N6-trimethyl-L-lysine is epsilon-N-trimethyl-L-lysine Rattus norvegicus 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.8 ascorbate required Rattus norvegicus