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Literature summary extracted from

  • Mercer, C.; Kaliappan, A.; Dennis, P.
    Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization (2008), Autophagy, 4, 185-194.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.5 glutathione S-transferase-BHMT fusion protein is expressed in HEK-293, T98G, A-10, MCF-7, H-1299, C2C12, and NIH-3T3 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.5 C217A the mutation reduces zinc binding by 95% while abrogating catalytic activity, the mutation has no effect on the fold increase of GST-BHMT proteolytic fragment in the absence of nutrients Homo sapiens
2.1.1.5 W352A the mutation disrupts stable BHMT multimerization, the mutant ablates catalytic activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.5 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.5 L-homocysteine + betaine
-
 Homo sapiens L-methionine + dimethylglycine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.5 tetramer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.1.1.5 betaine homocysteine methyltransferase
-
 Homo sapiens
2.1.1.5 BHMT
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.1.1.5 physiological function betaine homocysteine methyltransferase is a potential cargo-based end-point marker for macroautophagy Homo sapiens