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Literature summary extracted from

  • Cyrus, T.; Ding, T.; Pratico, D.
    Expression of thromboxane synthase, prostacyclin synthase and thromboxane receptor in atherosclerotic lesions: correlation with plaque composition (2010), Atherosclerosis, 208, 376-381.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.4 Prostaglandin H2 Mus musculus
-
 Prostaglandin I2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Mus musculus
-
-
-
5.3.99.5 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.4 aorta atherosclerotic aorta Mus musculus
-
5.3.99.5 aorta atherosclerotic aorta Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 Prostaglandin H2
-
 Mus musculus Prostaglandin I2
-
 ?
5.3.99.5 prostaglandin H2
-
 Mus musculus thromboxane A2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.4 PGIS
-
 Mus musculus
5.3.99.4 prostacyclin synthase
-
 Mus musculus
5.3.99.5 TXAS
-
 Mus musculus

Expression

EC Number Organism Comment Expression
5.3.99.4 Mus musculus after 16 weeks the prostacyclin synthase mRNA levels are reduced down
5.3.99.4 Mus musculus after 8 weeks on fat diet, aortic arches from low-density lipoprotein receptor deficient, LDL r-KO, mice shows a significant increase in prostacyclin synthase levels up
5.3.99.5 Mus musculus after 8 and 16 weeks on the fat diet, aortic arches from low-density lipoprotein receptor deficient mice show a significant increase in TXAS mRNA level when compared with control up