BRENDA - Enzyme Database show

Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine

Riederer, M.; Erwa, W.; Zimmermann, R.; Frank, S.; Zechner, R.; Atherosclerosis 204, 412-417 (2009)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.1.1.1
additional information
elevated enzyme activity during cell differentiation in adipose tissue
Mus musculus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.1
1-methylnicotinamide
product inhibition
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
Mus musculus
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
Homo sapiens
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.1
Homo sapiens
-
-
-
2.1.1.1
Mus musculus
-
female and male C57BL/6J mice
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.1
3T3-L1 cell
elevated enzyme activity during cell differentiation in adipose tissue
Mus musculus
-
2.1.1.1
adipocyte
-
Homo sapiens
-
2.1.1.1
adipocyte
NNMT expression profile, overview
Mus musculus
-
2.1.1.1
adipose tissue
-
Homo sapiens
-
2.1.1.1
adipose tissue
expression analysis, overview
Mus musculus
-
2.1.1.1
embryonic fibroblast
-
Mus musculus
-
2.1.1.1
liver
expression analysis, overview
Mus musculus
-
2.1.1.1
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
701990
Mus musculus
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
701990
Homo sapiens
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.1.1.1
37
-
assay at
Mus musculus
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.1
7.2
-
assay at
Mus musculus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.1.1.1
S-adenosyl-L-methionine
-
Homo sapiens
2.1.1.1
S-adenosyl-L-methionine
-
Mus musculus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.1.1.1
additional information
elevated enzyme activity during cell differentiation in adipose tissue
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.1.1.1
S-adenosyl-L-methionine
-
Homo sapiens
2.1.1.1
S-adenosyl-L-methionine
-
Mus musculus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.1
1-methylnicotinamide
product inhibition
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
Mus musculus
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
Homo sapiens
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.1
3T3-L1 cell
elevated enzyme activity during cell differentiation in adipose tissue
Mus musculus
-
2.1.1.1
adipocyte
-
Homo sapiens
-
2.1.1.1
adipocyte
NNMT expression profile, overview
Mus musculus
-
2.1.1.1
adipose tissue
-
Homo sapiens
-
2.1.1.1
adipose tissue
expression analysis, overview
Mus musculus
-
2.1.1.1
embryonic fibroblast
-
Mus musculus
-
2.1.1.1
liver
expression analysis, overview
Mus musculus
-
2.1.1.1
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
701990
Mus musculus
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
701990
Homo sapiens
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.1.1.1
37
-
assay at
Mus musculus
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.1
7.2
-
assay at
Mus musculus
Expression
EC Number
Organism
Commentary
Expression
2.1.1.1
Homo sapiens
the enzyme is induced by nicotinic acid in adipose tissue
up
2.1.1.1
Mus musculus
the enzyme is induced by nicotinic acid in white adipose tissue, but chronic treatment does not cause hyperhomocysteinemia, overview
up
Expression (protein specific)
EC Number
Organism
Commentary
Expression
2.1.1.1
Homo sapiens
the enzyme is induced by nicotinic acid in adipose tissue
up
2.1.1.1
Mus musculus
the enzyme is induced by nicotinic acid in white adipose tissue, but chronic treatment does not cause hyperhomocysteinemia, overview
up