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Literature summary extracted from

  • Weibel, G.L.; Joshi, M.R.; Alexander, E.T.; Zhu, P.; Blair, I.A.; Rothblat, G.H.
    Overexpression of human 15(S)-lipoxygenase-1 in RAW macrophages leads to increased cholesterol mobilization and reverse cholesterol transport (2009), Arterioscler. Thromb. Vasc. Biol., 29, 837-842.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.33 RAW 267.4 murine macrophages stably transfected to overexpress 15-LO-1 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15(S)-lipoxygenase-1
-
 Homo sapiens
1.13.11.33 15-LO-1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.13.11.33 physiological function overexpression of human 15-LO-1 in RAW macrophages promotes reverse cholesterol transport through increased cholesteryl ester hydrolysis and ABCA1-mediated cholesterol efflux Homo sapiens