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Literature summary extracted from

  • Lee, S.A.; Hwang, J.S.; Han, X.H.; Lee, C.; Lee, M.H.; Choe, S.G.; Hong, S.S.; Lee, D.; Lee, M.K.; Hwang, B.Y.
    Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase (2008), Arch. Pharm. Res., 31, 679-683.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 (2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)penta-2,4-dienamide i.e. guineensine, isolated from dried fruits of Piper longum, competitive inhibition; i.e. guineensine, isolated from dried fruits of Piper longum, competitive inhibition Mus musculus
1.4.3.4 (2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide i.e. methylpiperate, isolated from dried fruits of Piper longum, competitive inhibition; i.e. methylpiperate, isolated from dried fruits of Piper longum, competitive inhibition Mus musculus
1.4.3.4 additional information inhibitory potencies of methylpiperate derivatives from Piper longum, no inhibition by isolated piperlonguminine; inhibitory potencies of methylpiperate derivatives from Piper longum, no inhibition by isolated piperlonguminine Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 additional information
-
 additional information kinetics with substrate kynuramine Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrion
-
 Mus musculus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Mus musculus Q64133
-
-
1.4.3.4 Mus musculus Q8BW75
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 kynuramine + H2O + O2
-
 Mus musculus 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Mus musculus
1.4.3.4 MAO-B
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.4 0.0013
-
 (2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide inhibition of MAO-B Mus musculus
1.4.3.4 0.0235
-
 (2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide inhibition of MAO-A Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.4 0.0016
-
 inhibition of MAO-B Mus musculus (2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
1.4.3.4 0.0271
-
 inhibition of MAO-A Mus musculus (2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
1.4.3.4 0.139
-
 inhibition MAO-B Mus musculus (2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
1.4.3.4 0.139
-
 inhibition of MAO-A Mus musculus (2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)penta-2,4-dienamide