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Literature summary extracted from

  • Bailey, L.M.; Wallace, J.C.; Polyak, S.W.
    Holocarboxylase synthetase: correlation of protein localisation with biological function (2010), Arch. Biochem. Biophys., 496, 45-52.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.4.10 cytoplasm
-
 Homo sapiens 5737
-
6.3.4.10 mitochondria
-
 Homo sapiens
-
-
6.3.4.10 mitochondrion
-
 Homo sapiens 5739
-
6.3.4.10 additional information isozyme subcellular localization, immunofluorescence study, overview Homo sapiens
-
-
6.3.4.10 nucleus the longer Met58 isoform Homo sapiens 5634
-
6.3.4.15 cytoplasm
-
 Homo sapiens 5737
-
6.3.4.15 mitochondria
-
 Homo sapiens
-
-
6.3.4.15 mitochondrion
-
 Homo sapiens 5739
-
6.3.4.15 additional information isozyme subcellular localization, immunofluorescence study, overview Homo sapiens
-
-
6.3.4.15 nucleus the longer Met58 isoform Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.10 ATP + biotin + apo-[propionyl CoA carboxylase] Homo sapiens
-
 AMP + diphosphate + propionyl CoA carboxylase
-
 ?
6.3.4.10 additional information Homo sapiens although mammals have multiple biotin-dependent enzymes there is only a single gene encoding holocarboxylase synthetase, HCS, responsible for all cellular biotinylation. The enzyme catalyzes the reactions of EC 6.3.4.10, EC 6.3.4.11, and EC 6.3.4.15, overview ?
-
 ?
6.3.4.15 ATP + biotin + apo-[acetyl-CoA carboxylase] Homo sapiens
-
 AMP + diphosphate + acetyl-CoA carboxylase
-
 ?
6.3.4.15 additional information Homo sapiens although mammals have multiple biotin-dependent enzymes there is only a single gene encoding holocarboxylase synthetase, HCS, responsible for all cellular biotinylation. The enzyme catalyzes the reactions of EC 6.3.4.10, EC 6.3.4.11, and EC 6.3.4.15, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.10 Homo sapiens
-
 three isozymes that differ at the N-terminus
-
6.3.4.15 Homo sapiens
-
 three isozymes that differ at the N-terminus
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.10 HEK-293T cell
-
 Homo sapiens
-
6.3.4.10 HeLa cell
-
 Homo sapiens
-
6.3.4.10 liver
-
 Homo sapiens
-
6.3.4.10 T-lymphocyte
-
 Homo sapiens
-
6.3.4.15 HEK-293T cell
-
 Homo sapiens
-
6.3.4.15 HeLa cell
-
 Homo sapiens
-
6.3.4.15 liver
-
 Homo sapiens
-
6.3.4.15 T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.10 ATP + biotin + apo-[propionyl CoA carboxylase]
-
 Homo sapiens AMP + diphosphate + propionyl CoA carboxylase
-
 ?
6.3.4.10 additional information although mammals have multiple biotin-dependent enzymes there is only a single gene encoding holocarboxylase synthetase, HCS, responsible for all cellular biotinylation. The enzyme catalyzes the reactions of EC 6.3.4.10, EC 6.3.4.11, and EC 6.3.4.15, overview Homo sapiens ?
-
 ?
6.3.4.15 ATP + biotin + apo-[acetyl-CoA carboxylase]
-
 Homo sapiens AMP + diphosphate + acetyl-CoA carboxylase
-
 ?
6.3.4.15 additional information although mammals have multiple biotin-dependent enzymes there is only a single gene encoding holocarboxylase synthetase, HCS, responsible for all cellular biotinylation. The enzyme catalyzes the reactions of EC 6.3.4.10, EC 6.3.4.11, and EC 6.3.4.15, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.4.10 HCS
-
 Homo sapiens
6.3.4.10 Holocarboxylase synthetase
-
 Homo sapiens
6.3.4.15 HCS
-
 Homo sapiens
6.3.4.15 Holocarboxylase synthetase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
6.3.4.10 metabolism holocarboxylase synthetase governs the cellular fate of the essential micronutrient biotin, i.e. vitamin H or B7 Homo sapiens
6.3.4.10 physiological function HCS is responsible for attaching biotin onto the biotin-dependent enzymes that reside in the cytoplasm and mitochondria Homo sapiens
6.3.4.15 metabolism holocarboxylase synthetase governs the cellular fate of the essential micronutrient biotin, i.e. vitamin H or B7 Homo sapiens
6.3.4.15 physiological function HCS is responsible for attaching biotin onto the biotin-dependent enzymes that reside in the cytoplasm and mitochondria Homo sapiens