EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.182 | protein S21 | S21 probably inhibits KsgA activity in an indirect way, presumably by stabilizing 30S in a conformation that for whatever reason cannot be methylated by KsgA | Escherichia coli |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.182 | Escherichia coli | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.182 | 4 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA | recombinant KsgA is able to efficiently methylate 30S subunits isolated from strains of Escherichia coli resistant to kasugamycin, but not wild-type 30S subunits, indicating that the methylation function is specific for A1518 and A1519. KsgA is unable to utilize 30S subunits in the translationally active state as a substrate | Escherichia coli | 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.182 | KsgA | - |
Escherichia coli |