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Literature summary extracted from

  • Bansal, V.S.; Vaidya, S.
    Characterization of two distinct allyl pyrophosphatase activities from rat liver microsomes (1994), Arch. Biochem. Biophys., 315, 393-399.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.7.6 farnesyl monophosphate
-
 Rattus norvegicus
3.1.7.6 geranylgeranyl diphosphate potent noncompetitive inhibitor Rattus norvegicus
3.1.7.6 zaragozic acid B i.e. L694,581, mixed type inhibition at 0.04 mM. No inhibition by zaragozic acid A up to 0.1 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.7.6 additional information
-
 additional information the KM-value for (2E,6E)-farnesyl diphosphate increases with an increase in pH Rattus norvegicus
3.1.7.6 0.007
-
 (2E,6E)-farnesyl diphosphate pH 5.5, 37°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.7.6 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.7.6 additional information the activity is metal ion independent Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.7.6 (2E,6E)-farnesyl diphosphate + H2O Rattus norvegicus
-
 (2E,6E)-farnesol + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.7.6 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.7.6 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.7.6 0.0068
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.7.6 (2E,6E)-farnesyl diphosphate + H2O
-
 Rattus norvegicus (2E,6E)-farnesol + diphosphate
-
 ?
3.1.7.6 (2E,6E)-farnesyl diphosphate + H2O
-
 Rattus norvegicus (2E,6E)-farnesol + diphosphate diphosphate not determined ?

Synonyms

EC Number Synonyms Comment Organism
3.1.7.6 farnesyl pyrophosphatase
-
 Rattus norvegicus
3.1.7.6 FPPase
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.7.6 5.5
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.7.6 5 6.2 pH 5.0: about 45% of maximal activity, pH 6.2: about 75% of maximal activity Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.7.6 0.005
-
 pH 5.5, 37°C Rattus norvegicus geranylgeranyl diphosphate
3.1.7.6 0.02
-
-
 Rattus norvegicus zaragozic acid B
3.1.7.6 0.07
-
 pH 5.5, 37°C Rattus norvegicus farnesyl monophosphate