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Literature summary extracted from
- Microbial L-methioninase: production, molecular characterization, and therapeutic applications (2010), Appl. Microbiol. Biotechnol., 86, 445-467.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Entamoeba histolytica |
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Lactococcus lactis |
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Pseudomonas putida |
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Trichomonas vaginalis |
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Citrobacter freundii |
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Citrobacter intermedius |
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Clostridium sporogenes |
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Aeromonas sp. |
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Aspergillus sp. |
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Treponema denticola |
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Cladosporium cladosporioides |
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Aspergillus flavipes |
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Achromobacter starkeyi |
| 4.4.1.11 | medicine | enzyme therapy against various types of methionine-dependent tumors | Brevibacterium linens BL2 |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 4.4.1.11 | hanging-drop vapor-diffusion method | Entamoeba histolytica |
| 4.4.1.11 | hanging-drop vapor-diffusion method | Lactococcus lactis |
| 4.4.1.11 | hanging-drop vapor-diffusion method | Pseudomonas putida |
| 4.4.1.11 | hanging-drop vapor-diffusion method | Trichomonas vaginalis |
| 4.4.1.11 | hanging-drop vapor-diffusion method | Citrobacter freundii |
| 4.4.1.11 | hanging-drop vapor-diffusion method | Citrobacter intermedius |
| 4.4.1.11 | hanging-drop vapor-diffusion method | Clostridium sporogenes |
| 4.4.1.11 | hanging-drop vapor-diffusion method | Aeromonas sp. |
| 4.4.1.11 | hanging-drop vapor-diffusion method | Aspergillus sp. |
| 4.4.1.11 | hanging-drop vapor-diffusion method | Treponema denticola |
| 4.4.1.11 | hanging-drop vapor-diffusion method | Cladosporium cladosporioides |
| 4.4.1.11 | hanging-drop vapor-diffusion method | Aspergillus flavipes |
| 4.4.1.11 | hanging-drop vapor-diffusion method | Brevibacterium linens BL2 |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.11 | 2-mercaptoethanol | - |
Aspergillus flavipes |  |
| 4.4.1.11 | 2-mercaptoethanol | - |
Lactococcus lactis | |
| 4.4.1.11 | 3-Methyl-2-benzothiazolinone hydrazone | - |
Lactococcus lactis | |
| 4.4.1.11 | 5-5'-dithiobis-(2-nitrobenzoic acid) | - |
Brevibacterium linens BL2 | |
| 4.4.1.11 | 5-5'-dithiobis-(2-nitrobenzoic acid) | - |
Trichomonas vaginalis | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Achromobacter starkeyi | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Aeromonas sp. | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Aspergillus flavipes | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Aspergillus sp. | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Brevibacterium linens BL2 | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Citrobacter freundii | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Citrobacter intermedius | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Cladosporium cladosporioides | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Clostridium sporogenes | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Entamoeba histolytica | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Lactococcus lactis | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Pseudomonas putida | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Treponema denticola | |
| 4.4.1.11 | aminoethyloxyvinylglycine | - |
Trichomonas vaginalis | |
| 4.4.1.11 | DL-Penicillamine | - |
Brevibacterium linens BL2 | |
| 4.4.1.11 | DL-Penicillamine | - |
Trichomonas vaginalis | |
| 4.4.1.11 | DL-propargylglycine | - |
Brevibacterium linens BL2 | |
| 4.4.1.11 | DL-propargylglycine | - |
Trichomonas vaginalis | |
| 4.4.1.11 | DMSO | - |
Aspergillus flavipes | |
| 4.4.1.11 | DMSO | - |
Lactococcus lactis | |
| 4.4.1.11 | EDTA | - |
Aspergillus flavipes | |
| 4.4.1.11 | hydroxylamine | - |
Brevibacterium linens BL2 | |
| 4.4.1.11 | hydroxylamine | - |
Lactococcus lactis | |
| 4.4.1.11 | hydroxylamine | - |
Trichomonas vaginalis | |
| 4.4.1.11 | iodoacetamide | - |
Brevibacterium linens BL2 | |
| 4.4.1.11 | iodoacetamide | - |
Trichomonas vaginalis | |
| 4.4.1.11 | iodoacetate | - |
Achromobacter starkeyi | |
| 4.4.1.11 | iodoacetic acid | - |
Aspergillus flavipes | |
| 4.4.1.11 | iodoacetic acid | - |
Lactococcus lactis | |
| 4.4.1.11 | L-Cycloserine | - |
Brevibacterium linens BL2 | |
| 4.4.1.11 | L-Cycloserine | - |
Trichomonas vaginalis | |
| 4.4.1.11 | p-chloromercuri-benzoic acid | - |
Achromobacter starkeyi | |
| 4.4.1.11 | p-chloromercuri-benzoic acid | - |
Trichomonas vaginalis | |
| 4.4.1.11 | p-chloromercuribenzoic acid | - |
Brevibacterium linens BL2 | |
| 4.4.1.11 | propargylglycine | - |
Achromobacter starkeyi | |
| 4.4.1.11 | propargylglycine | - |
Aeromonas sp. | |
| 4.4.1.11 | propargylglycine | - |
Aspergillus flavipes | |
| 4.4.1.11 | propargylglycine | - |
Aspergillus sp. | |
| 4.4.1.11 | propargylglycine | - |
Brevibacterium linens BL2 | |
| 4.4.1.11 | propargylglycine | - |
Citrobacter freundii | |
| 4.4.1.11 | propargylglycine | - |
Citrobacter intermedius | |
| 4.4.1.11 | propargylglycine | - |
Cladosporium cladosporioides | |
| 4.4.1.11 | propargylglycine | - |
Clostridium sporogenes | |
| 4.4.1.11 | propargylglycine | - |
Entamoeba histolytica | |
| 4.4.1.11 | propargylglycine | - |
Lactococcus lactis | |
| 4.4.1.11 | propargylglycine | - |
Pseudomonas putida | |
| 4.4.1.11 | propargylglycine | - |
Treponema denticola | |
| 4.4.1.11 | propargylglycine | - |
Trichomonas vaginalis | |
| 4.4.1.11 | Semicarbazide | - |
Achromobacter starkeyi | |
| 4.4.1.11 | Sodium arsenate | - |
Achromobacter starkeyi | |
| 4.4.1.11 | Sodium azide | - |
Aspergillus flavipes | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.4.1.11 | additional information | - |
L-methionine | values between 0.8 to 1.7, depending on publications | Pseudomonas putida | |
| 4.4.1.11 | 0.0013 | - |
L-methionine | - |
Aspergillus sp. | |
| 4.4.1.11 | 0.1 | - |
trifluoromethionine | - |
Entamoeba histolytica | |
| 4.4.1.11 | 0.18 | - |
L-cysteine | - |
Citrobacter freundii | |
| 4.4.1.11 | 0.2 | - |
L-ethionine | - |
Pseudomonas putida | |
| 4.4.1.11 | 0.27 | - |
L-cystathionine | - |
Lactococcus lactis | |
| 4.4.1.11 | 0.45 | - |
L-ethionine | - |
Pseudomonas putida | |
| 4.4.1.11 | 0.46 | - |
L-cysteine | - |
Lactococcus lactis | |
| 4.4.1.11 | 0.5 | - |
DL-homocysteine | - |
Trichomonas vaginalis | |
| 4.4.1.11 | 0.5 | - |
L-ethionine | - |
Trichomonas vaginalis | |
| 4.4.1.11 | 0.53 | - |
L-cysteine | - |
Pseudomonas putida | |
| 4.4.1.11 | 0.55 | - |
L-methionine | - |
Treponema denticola | |
| 4.4.1.11 | 0.56 | - |
L-ethionine | - |
Citrobacter freundii | |
| 4.4.1.11 | 0.61 | - |
L-methionine | - |
Entamoeba histolytica | |
| 4.4.1.11 | 0.61 | - |
S-methyl-L-cysteine | - |
Citrobacter freundii | |
| 4.4.1.11 | 0.64 | - |
L-cysteine | - |
Entamoeba histolytica | |
| 4.4.1.11 | 0.7 | - |
L-methionine | - |
Citrobacter freundii | |
| 4.4.1.11 | 0.77 | - |
S-methylcysteine | - |
Pseudomonas putida | |
| 4.4.1.11 | 0.87 | - |
L-methionine | - |
Lactococcus lactis | |
| 4.4.1.11 | 1.1 | - |
DL-homocysteine | - |
Citrobacter freundii | |
| 4.4.1.11 | 1.13 | - |
L-methionine | - |
Citrobacter intermedius | |
| 4.4.1.11 | 1.33 | - |
L-methionine | - |
Pseudomonas putida | |
| 4.4.1.11 | 1.8 | - |
DL-homocysteine | - |
Pseudomonas putida | |
| 4.4.1.11 | 3.03 | - |
DL-homocysteine | - |
Entamoeba histolytica | |
| 4.4.1.11 | 3.6 | - |
L-cysteine | - |
Trichomonas vaginalis | |
| 4.4.1.11 | 4.3 | - |
L-methionine | - |
Trichomonas vaginalis | |
| 4.4.1.11 | 6.43 | - |
L-homocysteine | - |
Pseudomonas putida | |
| 4.4.1.11 | 30 | - |
L-homoserine | - |
Pseudomonas putida | |
| 4.4.1.11 | 90 | - |
L-methionine | - |
Clostridium sporogenes | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.4.1.11 | intracellular | - |
Entamoeba histolytica | 5622 | - |
| 4.4.1.11 | intracellular | - |
Lactococcus lactis | 5622 | - |
| 4.4.1.11 | intracellular | - |
Pseudomonas putida | 5622 | - |
| 4.4.1.11 | intracellular | - |
Trichomonas vaginalis | 5622 | - |
| 4.4.1.11 | intracellular | - |
Citrobacter freundii | 5622 | - |
| 4.4.1.11 | intracellular | - |
Citrobacter intermedius | 5622 | - |
| 4.4.1.11 | intracellular | - |
Clostridium sporogenes | 5622 | - |
| 4.4.1.11 | intracellular | - |
Aeromonas sp. | 5622 | - |
| 4.4.1.11 | intracellular | - |
Aspergillus sp. | 5622 | - |
| 4.4.1.11 | intracellular | - |
Treponema denticola | 5622 | - |
| 4.4.1.11 | intracellular | - |
Cladosporium cladosporioides | 5622 | - |
| 4.4.1.11 | intracellular | - |
Aspergillus flavipes | 5622 | - |
| 4.4.1.11 | intracellular | - |
Achromobacter starkeyi | 5622 | - |
| 4.4.1.11 | intracellular | - |
Brevibacterium linens BL2 | 5622 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.11 | Cd2+ | significant enzyme inhibition | Aspergillus flavipes | |
| 4.4.1.11 | Co2+ | slightly stimulatory effect on the enzyme activity | Aspergillus flavipes | |
| 4.4.1.11 | Cu2+ | slightly stimulatory effect on the enzyme activity | Aspergillus flavipes | |
| 4.4.1.11 | Li+ | significant enzyme inhibition | Aspergillus flavipes | |
| 4.4.1.11 | Mg2+ | slightly stimulatory effect on the enzyme activity | Aspergillus flavipes | |
| 4.4.1.11 | Mn2+ | slightly stimulatory effect on the enzyme activity | Aspergillus flavipes | |
| 4.4.1.11 | Na+ | significant enzyme inhibition | Aspergillus flavipes | |
| 4.4.1.11 | Ni2+ | slightly stimulatory effect on the enzyme activity | Aspergillus flavipes | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.11 | 37500 | - |
4 * 37500, SDS-PAGE | Clostridium sporogenes |
| 4.4.1.11 | 41000 | - |
4 * 41000, SDS-PAGE | Aeromonas sp. |
| 4.4.1.11 | 42600 | - |
4 * 42600, SDS-PAGE | Pseudomonas putida |
| 4.4.1.11 | 43000 | - |
4 * 43000, SDS-PAGE | Entamoeba histolytica |
| 4.4.1.11 | 43000 | - |
4 * 43000, SDS-PAGE | Citrobacter freundii |
| 4.4.1.11 | 43000 | - |
4 * 43000, SDS-PAGE | Brevibacterium linens BL2 |
| 4.4.1.11 | 44000 | - |
4 * 44000, SDS-PAGE | Trichomonas vaginalis |
| 4.4.1.11 | 45000 | - |
4 * 45000, SDS-PAGE | Pseudomonas putida |
| 4.4.1.11 | 55000 | - |
4 * 55000, SDS-PAGE | Lactococcus lactis |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.4.1.11 | Achromobacter starkeyi | - |
- |
- |
| 4.4.1.11 | Aeromonas sp. | - |
- |
- |
| 4.4.1.11 | Aspergillus flavipes | - |
- |
- |
| 4.4.1.11 | Aspergillus sp. | - |
- |
- |
| 4.4.1.11 | Aspergillus sp. Rs-1a | - |
- |
- |
| 4.4.1.11 | Brevibacterium linens BL2 | - |
- |
- |
| 4.4.1.11 | Citrobacter freundii | - |
- |
- |
| 4.4.1.11 | Citrobacter intermedius | - |
- |
- |
| 4.4.1.11 | Cladosporium cladosporioides | - |
- |
- |
| 4.4.1.11 | Clostridium sporogenes | - |
- |
- |
| 4.4.1.11 | Entamoeba histolytica | - |
- |
- |
| 4.4.1.11 | Lactococcus lactis | - |
- |
- |
| 4.4.1.11 | no activity in mammalia | - |
- |
- |
| 4.4.1.11 | Pseudomonas putida | - |
- |
- |
| 4.4.1.11 | Treponema denticola | - |
- |
- |
| 4.4.1.11 | Trichomonas vaginalis | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.4.1.11 | ion exchange and gel filtration chromatography | Entamoeba histolytica |
| 4.4.1.11 | ion exchange and gel filtration chromatography | Lactococcus lactis |
| 4.4.1.11 | ion exchange and gel filtration chromatography | Pseudomonas putida |
| 4.4.1.11 | ion exchange and gel filtration chromatography | Trichomonas vaginalis |
| 4.4.1.11 | ion exchange and gel filtration chromatography | Citrobacter freundii |
| 4.4.1.11 | ion exchange and gel filtration chromatography | Citrobacter intermedius |
| 4.4.1.11 | ion exchange and gel filtration chromatography | Clostridium sporogenes |
| 4.4.1.11 | ion exchange and gel filtration chromatography | Aeromonas sp. |
| 4.4.1.11 | ion exchange and gel filtration chromatography | Aspergillus sp. |
| 4.4.1.11 | ion exchange and gel filtration chromatography | Treponema denticola |
| 4.4.1.11 | ion exchange and gel filtration chromatography | Cladosporium cladosporioides |
| 4.4.1.11 | ion exchange and gel filtration chromatography | Aspergillus flavipes |
| 4.4.1.11 | ion exchange and gel filtration chromatography | Brevibacterium linens BL2 |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.11 | additional information | - |
value is 0.04 U/mg protein | Lactococcus lactis |
| 4.4.1.11 | additional information | - |
value is 0.26 U/mg protein | Citrobacter intermedius |
| 4.4.1.11 | additional information | - |
value is 0.44 U/mg protein | Entamoeba histolytica |
| 4.4.1.11 | additional information | - |
value is 1.8 U/mg protein | Pseudomonas putida |
| 4.4.1.11 | additional information | - |
value is 10 U/mg protein | Citrobacter freundii |
| 4.4.1.11 | additional information | - |
value is 228.9 U/mg protein | Brevibacterium linens BL2 |
| 4.4.1.11 | additional information | - |
value is 3.17 U/mg protein | Trichomonas vaginalis |
| 4.4.1.11 | additional information | - |
value is 31.0 U/mg protein | Aeromonas sp. |
| 4.4.1.11 | additional information | - |
value is 36.6 U/mg protein | Treponema denticola |
| 4.4.1.11 | additional information | - |
value is 44.8 U/mg protein | Aspergillus sp. |
| 4.4.1.11 | additional information | - |
value is 45.3 U/mg protein | Pseudomonas putida |
| 4.4.1.11 | additional information | - |
value is 61 U/mg protein | Aspergillus flavipes |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.4.1.11 | cystathionine + ? | - |
Brevibacterium linens BL2 | ? | - |
? | |
| 4.4.1.11 | DL-ethionine + H2O | - |
Brevibacterium linens BL2 | ? | - |
? | |
| 4.4.1.11 | DL-homocysteic acid + H2O | - |
Trichomonas vaginalis | ? | - |
? | |
| 4.4.1.11 | DL-homocysteine + H2O | - |
Entamoeba histolytica | ? | - |
? | |
| 4.4.1.11 | DL-homocysteine + H2O | - |
Pseudomonas putida | ? | - |
? | |
| 4.4.1.11 | DL-homocysteine + H2O | - |
Trichomonas vaginalis | ? | - |
? | |
| 4.4.1.11 | DL-homocysteine + H2O | - |
Citrobacter freundii | ? | - |
? | |
| 4.4.1.11 | DL-homocysteine + H2O | - |
Clostridium sporogenes | ? | - |
? | |
| 4.4.1.11 | DL-homocysteine + H2O | - |
Aspergillus sp. | ? | - |
? | |
| 4.4.1.11 | DL-homocysteine + H2O | - |
Brevibacterium linens BL2 | ? | - |
? | |
| 4.4.1.11 | DL-homocysteine + H2O | - |
Aspergillus sp. Rs-1a | ? | - |
? | |
| 4.4.1.11 | L-cystathionine + ? | - |
Lactococcus lactis | ? | - |
? | |
| 4.4.1.11 | L-cysteine + H2O | - |
Entamoeba histolytica | ? | - |
? | |
| 4.4.1.11 | L-cysteine + H2O | - |
Lactococcus lactis | ? | - |
? | |
| 4.4.1.11 | L-cysteine + H2O | - |
Pseudomonas putida | ? | - |
? | |
| 4.4.1.11 | L-cysteine + H2O | - |
Trichomonas vaginalis | ? | - |
? | |
| 4.4.1.11 | L-cysteine + H2O | - |
Citrobacter freundii | ? | - |
? | |
| 4.4.1.11 | L-cysteine + H2O | - |
Clostridium sporogenes | ? | - |
? | |
| 4.4.1.11 | L-cysteine + H2O | - |
Brevibacterium linens BL2 | ? | - |
? | |
| 4.4.1.11 | L-ethionine + H2O | - |
Pseudomonas putida | ? | - |
? | |
| 4.4.1.11 | L-ethionine + H2O | - |
Trichomonas vaginalis | ? | - |
? | |
| 4.4.1.11 | L-ethionine + H2O | - |
Citrobacter freundii | ? | - |
? | |
| 4.4.1.11 | L-ethionine + H2O | - |
Clostridium sporogenes | ? | - |
? | |
| 4.4.1.11 | L-ethionine + H2O | - |
Aeromonas sp. | ? | - |
? | |
| 4.4.1.11 | L-ethionine + H2O | - |
Aspergillus sp. | ? | - |
? | |
| 4.4.1.11 | L-ethionine + H2O | - |
Aspergillus sp. Rs-1a | ? | - |
? | |
| 4.4.1.11 | L-homocysteine + H2O | - |
Pseudomonas putida | ? | - |
? | |
| 4.4.1.11 | L-homocysteine + H2O | - |
Aeromonas sp. | ? | - |
? | |
| 4.4.1.11 | L-homoserine + H2O | - |
Pseudomonas putida | ? | - |
? | |
| 4.4.1.11 | L-homoserine + H2O | - |
Aspergillus sp. | ? | - |
? | |
| 4.4.1.11 | L-homoserine + H2O | - |
Aspergillus sp. Rs-1a | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Entamoeba histolytica | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Lactococcus lactis | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Pseudomonas putida | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Trichomonas vaginalis | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Citrobacter freundii | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Citrobacter intermedius | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Clostridium sporogenes | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Aeromonas sp. | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Aspergillus sp. | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Treponema denticola | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Cladosporium cladosporioides | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Aspergillus flavipes | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Brevibacterium linens BL2 | ? | - |
? | |
| 4.4.1.11 | L-methionine + H2O | - |
Aspergillus sp. Rs-1a | ? | - |
? | |
| 4.4.1.11 | L-selenomethionine + H2O | - |
Trichomonas vaginalis | ? | - |
? | |
| 4.4.1.11 | O-acetyl-L-homoserine + H2O | - |
Aeromonas sp. | ? | - |
? | |
| 4.4.1.11 | S-methyl-L-cysteine + H2O | - |
Citrobacter freundii | ? | - |
? | |
| 4.4.1.11 | S-methylcysteine + H2O | - |
Pseudomonas putida | ? | - |
? | |
| 4.4.1.11 | trifluoromethionine + H2O | - |
Entamoeba histolytica | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.4.1.11 | tetramer | - |
Citrobacter intermedius |
| 4.4.1.11 | tetramer | - |
Aspergillus sp. |
| 4.4.1.11 | tetramer | - |
Cladosporium cladosporioides |
| 4.4.1.11 | tetramer | - |
Aspergillus flavipes |
| 4.4.1.11 | tetramer | - |
Achromobacter starkeyi |
| 4.4.1.11 | tetramer | 4 * 43000, SDS-PAGE | Entamoeba histolytica |
| 4.4.1.11 | tetramer | 4 * 43000, SDS-PAGE | Citrobacter freundii |
| 4.4.1.11 | tetramer | 4 * 43000, SDS-PAGE | Brevibacterium linens BL2 |
| 4.4.1.11 | tetramer | 4 * 45000, SDS-PAGE | Pseudomonas putida |
| 4.4.1.11 | tetramer | 4 * 41000, SDS-PAGE | Aeromonas sp. |
| 4.4.1.11 | tetramer | 4 * 55000, SDS-PAGE | Lactococcus lactis |
| 4.4.1.11 | tetramer | 4 * 37500, SDS-PAGE | Clostridium sporogenes |
| 4.4.1.11 | tetramer | 4 * 44000, SDS-PAGE | Trichomonas vaginalis |
| 4.4.1.11 | tetramer | 4 * 42600, SDS-PAGE | Pseudomonas putida |
| 4.4.1.11 | tetramer | 4*43500, SDS-PAGE | Treponema denticola |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.4.1.11 | L-methioninase | - |
Entamoeba histolytica |
| 4.4.1.11 | L-methioninase | - |
Lactococcus lactis |
| 4.4.1.11 | L-methioninase | - |
Pseudomonas putida |
| 4.4.1.11 | L-methioninase | - |
Trichomonas vaginalis |
| 4.4.1.11 | L-methioninase | - |
Citrobacter freundii |
| 4.4.1.11 | L-methioninase | - |
Citrobacter intermedius |
| 4.4.1.11 | L-methioninase | - |
Clostridium sporogenes |
| 4.4.1.11 | L-methioninase | - |
Aeromonas sp. |
| 4.4.1.11 | L-methioninase | - |
Aspergillus sp. |
| 4.4.1.11 | L-methioninase | - |
Treponema denticola |
| 4.4.1.11 | L-methioninase | - |
Cladosporium cladosporioides |
| 4.4.1.11 | L-methioninase | - |
Aspergillus flavipes |
| 4.4.1.11 | L-methioninase | - |
Achromobacter starkeyi |
| 4.4.1.11 | L-methioninase | - |
Brevibacterium linens BL2 |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.11 | 25 | - |
- |
Brevibacterium linens BL2 |
| 4.4.1.11 | 30 | - |
- |
Lactococcus lactis |
| 4.4.1.11 | 30 | - |
- |
Citrobacter freundii |
| 4.4.1.11 | 30 | - |
- |
Citrobacter intermedius |
| 4.4.1.11 | 30 | - |
- |
Cladosporium cladosporioides |
| 4.4.1.11 | 30 | - |
- |
Aspergillus flavipes |
| 4.4.1.11 | 35 | - |
- |
Aspergillus sp. |
| 4.4.1.11 | 37 | - |
- |
Entamoeba histolytica |
| 4.4.1.11 | 37 | - |
- |
Pseudomonas putida |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.4.1.11 | additional information | - |
L-methionine | values between 25.3 to 48.6, depending on publications | Pseudomonas putida | |
| 4.4.1.11 | 0.81 | - |
trifluoromethionine | - |
Entamoeba histolytica | |
| 4.4.1.11 | 1.4 | - |
L-homoserine | - |
Pseudomonas putida | |
| 4.4.1.11 | 1.59 | - |
L-cysteine | - |
Entamoeba histolytica | |
| 4.4.1.11 | 1.82 | - |
L-methionine | - |
Entamoeba histolytica | |
| 4.4.1.11 | 2.27 | - |
L-cysteine | - |
Pseudomonas putida | |
| 4.4.1.11 | 2.3 | - |
L-cysteine | - |
Citrobacter freundii | |
| 4.4.1.11 | 3.92 | - |
DL-homocysteine | - |
Entamoeba histolytica | |
| 4.4.1.11 | 5.1 | - |
DL-homocysteine | - |
Citrobacter freundii | |
| 4.4.1.11 | 5.9 | - |
S-methyl-L-cysteine | - |
Citrobacter freundii | |
| 4.4.1.11 | 6.2 | - |
L-ethionine | - |
Citrobacter freundii | |
| 4.4.1.11 | 6.5 | - |
L-methionine | - |
Citrobacter freundii | |
| 4.4.1.11 | 33.4 | - |
L-ethionine | - |
Pseudomonas putida | |
| 4.4.1.11 | 44.8 | - |
DL-homocysteine | - |
Pseudomonas putida | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.11 | 7 | - |
- |
Entamoeba histolytica |
| 4.4.1.11 | 7.2 | - |
- |
Pseudomonas putida |
| 4.4.1.11 | 7.5 | - |
- |
Brevibacterium linens BL2 |
| 4.4.1.11 | 8 | - |
- |
Pseudomonas putida |
| 4.4.1.11 | 8 | - |
- |
Citrobacter freundii |
| 4.4.1.11 | 8 | - |
- |
Aeromonas sp. |
| 4.4.1.11 | 8 | - |
- |
Aspergillus sp. |
| 4.4.1.11 | 8 | - |
- |
Aspergillus flavipes |
| 4.4.1.11 | 9 | - |
- |
Cladosporium cladosporioides |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.11 | 7 | 8 | - |
Trichomonas vaginalis |
| 4.4.1.11 | 7.5 | 8.5 | - |
Clostridium sporogenes |
pH Stability
| EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.11 | 5.6 | 8.2 | - |
Entamoeba histolytica |
| 4.4.1.11 | 6 | 9 | - |
Pseudomonas putida |
| 4.4.1.11 | 6 | 9 | - |
Aeromonas sp. |
| 4.4.1.11 | 6 | 8 | - |
Brevibacterium linens BL2 |
| 4.4.1.11 | 6 | 10 | - |
Pseudomonas putida |
| 4.4.1.11 | 6.5 | 9 | - |
Trichomonas vaginalis |
| 4.4.1.11 | 8 | 9 | - |
Aspergillus sp. |
| 4.4.1.11 | 8 | 9 | - |
Aspergillus flavipes |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Entamoeba histolytica | |
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Lactococcus lactis | |
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Pseudomonas putida | |
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Trichomonas vaginalis | |
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Citrobacter freundii | |
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Citrobacter intermedius | |
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Clostridium sporogenes | |
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Aeromonas sp. | |
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Aspergillus sp. | |
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Treponema denticola | |
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Cladosporium cladosporioides | |
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Aspergillus flavipes | |
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Achromobacter starkeyi | |
| 4.4.1.11 | pyridoxal 5'-phosphate | - |
Brevibacterium linens BL2 | |
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Release 2023.1 (January 2023)
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