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Literature summary extracted from

  • Antoniani, D.; Bocci, P.; Maciag, A.; Raffaelli, N.; Landini, P.
    Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell assays suitable for high-throughput screening of biofilm inhibitors (2010), Appl. Microbiol. Biotechnol., 85, 1095-1104.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.7.65 medicine diguanylate cyclases are interesting targets for new antimicrobial agents with biofilm activity Escherichia coli

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.65 into the pTOPO vector Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.65 additional information a mutant, carrying an adrA mutation resulting in GGDEF -> GGAAF change in AdrA protein catalytic site, is constructed Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.65 sulfathiazole
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.65 GTP Escherichia coli
-
 diphosphate + cyclic di-3',5'-guanylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.65 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.65 GTP
-
 Escherichia coli diphosphate + cyclic di-3',5'-guanylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.65 AdrA
-
 Escherichia coli
2.7.7.65 DGC
-
 Escherichia coli
2.7.7.65 diguanylate cyclase
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
2.7.7.65 physiological function in Gram-negative bacteria production of of cyclic di-3',5'-guanylate, c-di-GMP, is the main trigger for production of extracellular polysaccharides and for biofilm formation Escherichia coli