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Literature summary extracted from

  • Mu, H.; Lue, Z.R.; Park, D.; Kim, B.C.; Bhak, J.; Zou, F.; Yang, J.M.; Li, S.; Park, Y.D.; Zou, H.C.; Zhou, H.M.
    Kinetics of Zn2+-induced brain type creatine kinase unfolding and aggregation (2010), Appl. Biochem. Biotechnol., 160, 1309-1320.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.3.2 Zn2+ Zn2+ may induce CK-BB inactivation and misfolding, when the Zn2+ concentration is 0.4 mM, CK-BB activity is completely abolished Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.3.2 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.3.2 DEAE Sepharose column chromatography and Sephadex G-200 gel filtration Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.3.2 brain
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.3.2 2.99
-
 crude homogenate Oryctolagus cuniculus
2.7.3.2 205.1
-
 after 68.6fold purification Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.3.2 ATP + creatine
-
 Oryctolagus cuniculus ADP + creatine phosphate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.7.3.2 ATP: creatine N-phosphotransferase
-
 Oryctolagus cuniculus
2.7.3.2 brain type creatine kinase
-
 Oryctolagus cuniculus
2.7.3.2 CK-BB
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.3.2 ATP
-
 Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.3.2 0.15
-
 at 25°C Oryctolagus cuniculus Zn2+