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Literature summary extracted from

  • Bowker, K.E.; Caspers, P.; Gaucher, B.; MacGowan, A.P.
    In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of Gram-positive bacteria (2009), Antimicrob. Agents Chemother., 53, 4949-4952.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.3 BAL0030543 a dihydrophthalazine inhibitor with antibacterial activity, overview Staphylococcus aureus
1.5.1.3 BAL0030543 a dihydrophthalazine inhibitor with antibacterial activity, overview Streptococcus mitis
1.5.1.3 BAL0030543 a dihydrophthalazine inhibitor with antibacterial activity, overview Streptococcus pneumoniae
1.5.1.3 BAL0030544 a dihydrophthalazine inhibitor with antibacterial activity, overview Staphylococcus aureus
1.5.1.3 BAL0030544 a dihydrophthalazine inhibitor with antibacterial activity, overview Streptococcus mitis
1.5.1.3 BAL0030544 a dihydrophthalazine inhibitor with antibacterial activity, overview Streptococcus pneumoniae
1.5.1.3 BAL0030545 a dihydrophthalazine inhibitor with antibacterial activity, overview Staphylococcus aureus
1.5.1.3 BAL0030545 a dihydrophthalazine inhibitor with antibacterial activity, overview Streptococcus mitis
1.5.1.3 BAL0030545 a dihydrophthalazine inhibitor with antibacterial activity, overview Streptococcus pneumoniae
1.5.1.3 trimethoprim
-
Staphylococcus aureus
1.5.1.3 trimethoprim
-
Streptococcus mitis
1.5.1.3 trimethoprim
-
Streptococcus pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Staphylococcus aureus
-
methicillin-sensitive and -resistant strains
-
1.5.1.3 Streptococcus mitis
-
methicillin-sensitive and -resistant strains
-
1.5.1.3 Streptococcus pneumoniae
-
methicillin-sensitive and -resistant strains
-

Synonyms

EC Number Synonyms Comment Organism
1.5.1.3 DHFR
-
Staphylococcus aureus
1.5.1.3 DHFR
-
Streptococcus pneumoniae
1.5.1.3 DHFR
-
Streptococcus mitis

General Information

EC Number General Information Comment Organism
1.5.1.3 physiological function dihydrofolate reductase is an enzyme with a pivotal role in the synthesis of intracellular tetrahydrofolic acid, which is essential in the synthesis of purines, some amino acids, and thymidine. DHFR is the sole source of tetrahydrofolic acid Staphylococcus aureus
1.5.1.3 physiological function dihydrofolate reductase is an enzyme with a pivotal role in the synthesis of intracellular tetrahydrofolic acid, which is essential in the synthesis of purines, some amino acids, and thymidine. DHFR is the sole source of tetrahydrofolic acid Streptococcus pneumoniae
1.5.1.3 physiological function dihydrofolate reductase is an enzyme with a pivotal role in the synthesis of intracellular tetrahydrofolic acid, which is essential in the synthesis of purines, some amino acids, and thymidine. DHFR is the sole source of tetrahydrofolic acid Streptococcus mitis