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Literature summary extracted from

  • Barker, R.H.; Liu, H.; Hirth, B.; Celatka, C.A.; Fitzpatrick, R.; Xiang, Y.; Willert, E.K.; Phillips, M.A.; Kaiser, M.; Bacchi, C.J.; Rodriguez, A.; Yarlett, N.; Klinger, J.D.; Sybertz, E.
    Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis (2009), Antimicrob. Agents Chemother., 53, 2052-2058.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.50 expressed in Escherichia coli Homo sapiens
4.1.1.50 expressed in Escherichia coli Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.50 Genz-643990
-
 Homo sapiens
4.1.1.50 Genz-643990
-
 Trypanosoma brucei
4.1.1.50 Genz-644043
-
 Homo sapiens
4.1.1.50 Genz-644043
-
 Trypanosoma brucei
4.1.1.50 Genz-644053
-
 Homo sapiens
4.1.1.50 Genz-644053
-
 Trypanosoma brucei
4.1.1.50 Genz-644131
-
 Homo sapiens
4.1.1.50 Genz-644131
-
 Trypanosoma brucei
4.1.1.50 MDL73811 irreversible inhibitor Homo sapiens
4.1.1.50 MDL73811 irreversible inhibitor Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.50 Homo sapiens
-
-
-
4.1.1.50 Trypanosoma brucei
-
 subspecies Trypanosoma brucei rhodesiense strain STIB 900 and subspecies Trypanosoma brucei brucei strains LAB 110 EATRO and STIB 795
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.50 Ni2+-agarose column chromatography Homo sapiens
4.1.1.50 Ni2+-agarose column chromatography Trypanosoma brucei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.50 S-adenosyl-L-methionine
-
 Homo sapiens (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Trypanosoma brucei (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.50 AdoMetDC
-
 Homo sapiens
4.1.1.50 AdoMetDC
-
 Trypanosoma brucei
4.1.1.50 S-Adenosylmethionine decarboxylase
-
 Homo sapiens
4.1.1.50 S-Adenosylmethionine decarboxylase
-
 Trypanosoma brucei

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.50 pyridoxal 5'-phosphate
-
 Homo sapiens
4.1.1.50 pyridoxal 5'-phosphate
-
 Trypanosoma brucei