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Literature summary extracted from

  • Drygin, D.; Rice, W.G.; Grummt, I.
    The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer (2010), Annu. Rev. Pharmacol. Toxicol., 50, 131-156.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.6 CK2 is associated with Pol I, the initiation-competent subclass of Pol I, CK2 phosphorylates a number of proteins involved in Pol I transcription and pre-rRNA processing, including UBF, TIF-IA, SL1/TIF-IB, topoisomerase IIa, nucleolin, and nucleophosmin, overview Mus musculus
2.7.7.6 CK2 is associated with Pol I, the initiation-competent subclass of Pol I, CK2 phosphorylates a number of proteins involved in Pol I transcription and pre-rRNA processing, including UBF, TIF-IA, SL1/TIF-IB, topoisomerase IIa, nucleolin, and nucleophosmin, overview Homo sapiens
2.7.7.6 additional information The activity of basal Pol I factors is regulated by posttranslational modifications Mus musculus
2.7.7.6 additional information The activity of basal Pol I factors is regulated by posttranslational modifications Homo sapiens
2.7.7.6 PAF53 a 53-kDa protein that is associated with Pol I, recruitment of Pol I to the pre-initiation complex requires the interaction of UBF with SL1/TIF-IB and with PAF53 Mus musculus
2.7.7.6 PAF53 a 53-kDa protein that is associated with Pol I, recruitment of Pol I to the pre-initiation complex requires the interaction of UBF with SL1/TIF-IB and with PAF53 Homo sapiens
2.7.7.6 TAFI protein performs important tasks in transcription complex assembly, mediating specific interactions between the rDNA promoter and Pol I, thereby recruiting Pol I, together with a collection of Pol I-associated factors, to rDNA Mus musculus
2.7.7.6 TAFI protein performs important tasks in transcription complex assembly, mediating specific interactions between the rDNA promoter and Pol I, thereby recruiting Pol I, together with a collection of Pol I-associated factors, to rDNA Homo sapiens
2.7.7.6 TIF-IB/SL 1 Pol I promoter specificity is conferred by TIF-IB/SL1, a protein complex containing the TATA binding protein and five TATA binding protein-associated factors, including TAFI110/95, TAFI68, TAFI48, TAFI35, and TAFI12 Mus musculus
2.7.7.6 TIF-IB/SL 1 Pol I promoter specificity is conferred by TIF-IB/SL1, a protein complex containing the TATA binding protein and five TATA binding protein-associated factors, including TAFI110/95, TAFI68, TAFI48, TAFI35, and TAFI12 Homo sapiens
2.7.7.6 upstream binding factor UBF, activates rRNA gene transcription by several means, for example, by recruiting Pol I to the rDNA promoter, by stabilizing binding of TIF-IB/SL1, and by displacing nonspecific DNA binding proteins such as histone H1. And UBF has additional roles in regulation of Pol I promoter escape and transcription elongation Mus musculus
2.7.7.6 upstream binding factor UBF, activates rRNA gene transcription by several means, for example, by recruiting Pol I to the rDNA promoter, by stabilizing binding of TIF-IB/SL1, and by displacing nonspecific DNA binding proteins such as histone H1. And UBF has additional roles in regulation of Pol I promoter escape and transcription elongation Homo sapiens

Application

EC Number Application Comment Organism
2.7.7.6 drug development development of drugs that target the Pol I transcription machinery at different points for use in cancer therapies, overview Mus musculus
2.7.7.6 drug development development of drugs that target the Pol I transcription machinery at different points for use in cancer therapies, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.6 additional information oncogenes and tumor suppressors control Pol I transcription, overview. Development of drugs that target the Pol I transcription machinery at different points, overveiw Homo sapiens
2.7.7.6 additional information oncogenes and tumor suppressors control Pol I transcription, overview. Development of drugs that target the Pol I transcription machinery at different points, overveiw Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.6 nucleus
-
 Mus musculus 5634
-
2.7.7.6 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.6 additional information Mus musculus two distinct forms, Pol Ialpha and Pol Ibeta. Both forms are catalytically active, but only Pol Ibeta can assemble into productive transcription initiation complexes. Regulation of Pol I transcription during cell cycle progression involving cytokines, and structural organization of mammalian rDNA repeats and the basal factors required for transcription initiation, overview. The activity of basal Pol I factors is regulated by posttranslational modifications ?
-
 ?
2.7.7.6 additional information Homo sapiens two distinct forms, Pol Ialpha and Pol Ibeta. Both forms are catalytically active, but only Pol Ibeta can assemble into productive transcription initiation complexes. Regulation of Pol I transcription during cell cycle progression involving cytokines, and structural organization of mammalian rDNA repeats and the basal factors required for transcription initiation, overview. The activity of basal Pol I factors is regulated by posttranslational modifications ?
-
 ?
2.7.7.6 nucleoside triphosphate + RNAn Mus musculus template is DNA, epigenetic control of rDNA transcription, regulation system of RNA polymerase, detailed overview diphosphate + RNAn+1
-
 ?
2.7.7.6 nucleoside triphosphate + RNAn Homo sapiens template is DNA, epigenetic control of rDNA transcription, regulation system of RNA polymerase, detailed overview diphosphate + RNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.6 Homo sapiens
-
-
-
2.7.7.6 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.7.6 additional information The activity of basal Pol I factors is regulated by posttranslational modifications, overview, e.g. acetylation is a posttranslational modification that regulates the activity of basal Pol I transcription factors, including UBF and SL1/TIF-IB Mus musculus
2.7.7.6 additional information The activity of basal Pol I factors is regulated by posttranslational modifications, overview, e.g. acetylation is a posttranslational modification that regulates the activity of basal Pol I transcription factors, including UBF and SL1/TIF-IB Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.6 carcinoma cell
-
 Mus musculus
-
2.7.7.6 carcinoma cell
-
 Homo sapiens
-
2.7.7.6 fibroblast
-
 Mus musculus
-
2.7.7.6 fibroblast
-
 Homo sapiens
-
2.7.7.6 lung
-
 Mus musculus
-
2.7.7.6 lung
-
 Homo sapiens
-
2.7.7.6 additional information aside from growth-dependent regulation, Pol I transcription also oscillates during cell cycle progression. Transcription is maximal during S- and G2-phase, subsides during mitosis, and then slowly recovers during G1-phase Mus musculus
-
2.7.7.6 additional information aside from growth-dependent regulation, Pol I transcription also oscillates during cell cycle progression. Transcription is maximal during S- and G2-phase, subsides during mitosis, and then slowly recovers during G1-phase Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.6 additional information two distinct forms, Pol Ialpha and Pol Ibeta. Both forms are catalytically active, but only Pol Ibeta can assemble into productive transcription initiation complexes. Regulation of Pol I transcription during cell cycle progression involving cytokines, and structural organization of mammalian rDNA repeats and the basal factors required for transcription initiation, overview. The activity of basal Pol I factors is regulated by posttranslational modifications Mus musculus ?
-
 ?
2.7.7.6 additional information two distinct forms, Pol Ialpha and Pol Ibeta. Both forms are catalytically active, but only Pol Ibeta can assemble into productive transcription initiation complexes. Regulation of Pol I transcription during cell cycle progression involving cytokines, and structural organization of mammalian rDNA repeats and the basal factors required for transcription initiation, overview. The activity of basal Pol I factors is regulated by posttranslational modifications Homo sapiens ?
-
 ?
2.7.7.6 nucleoside triphosphate + RNAn template is DNA Mus musculus diphosphate + RNAn+1
-
 ?
2.7.7.6 nucleoside triphosphate + RNAn template is DNA Homo sapiens diphosphate + RNAn+1
-
 ?
2.7.7.6 nucleoside triphosphate + RNAn template is DNA, epigenetic control of rDNA transcription, regulation system of RNA polymerase, detailed overview Mus musculus diphosphate + RNAn+1
-
 ?
2.7.7.6 nucleoside triphosphate + RNAn template is DNA, epigenetic control of rDNA transcription, regulation system of RNA polymerase, detailed overview Homo sapiens diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.6 Pol I
-
 Mus musculus
2.7.7.6 Pol I
-
 Homo sapiens
2.7.7.6 RNA polymerase I
-
 Mus musculus
2.7.7.6 RNA polymerase I
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.7.6 Mus musculus mitotic silencing of Pol I transcription is caused by Cdk1/cyclin B-dependent phosphorylation of a single threonine residue Thr852 at TAFI110 that impairs the interaction of SL1/TIF-IB with UBF down
2.7.7.6 Homo sapiens mitotic silencing of Pol I transcription is caused by Cdk1/cyclin B-dependent phosphorylation of a single threonine residue Thr852 at TAFI110 that impairs the interaction of SL1/TIF-IB with UBF down
2.7.7.6 Mus musculus at the end of mitosis, Cdc14B, a phosphatase that is sequestered in an inactive state in the nucleolus during interphase and is released from rDNA during mitosis, dephosphorylates Thr852, thereby activating SL1 and relieving mitotic repression of Pol I transcription up
2.7.7.6 Homo sapiens at the end of mitosis, Cdc14B, a phosphatase that is sequestered in an inactive state in the nucleolus during interphase and is released from rDNA during mitosis, dephosphorylates Thr852, thereby activating SL1 and relieving mitotic repression of Pol I transcription up

General Information

EC Number General Information Comment Organism
2.7.7.6 physiological function detailed overview Mus musculus
2.7.7.6 physiological function detailed overview Homo sapiens