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Literature summary extracted from

  • Pasqualini, J.R.
    Estrogen sulfotransferases in breast and endometrial cancers (2009), Ann. N. Y. Acad. Sci., 1155, 88-98.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.4 3beta-hydroxytibolone 102% stimulation of activity at 0.0005 mM Homo sapiens
2.8.2.4 celecoxib
-
Homo sapiens
2.8.2.4 medrogestone 85% stimulation of activity at 0.0005 mM Homo sapiens
2.8.2.4 nomegestrol acetate 42% stimulation of activity at 0.0005 mM Homo sapiens
2.8.2.4 Promegestone 31% stimulation of activity at 0.0005 mM Homo sapiens
2.8.2.4 quercetin
-
Homo sapiens
2.8.2.4 resveratrol
-
Homo sapiens
2.8.2.4 tibolone 41% stimulation of activity at 0.0005 mM Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.4 resveratrol
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.4 cytosol
-
Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.4 35000
-
SULT1E1 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.4 breast cancer cell
-
Homo sapiens
-
2.8.2.4 Human-7 cell
-
Homo sapiens
-
2.8.2.4 mammary gland estrogen sulfotransferase is significantly more active in the normal breast cell than in the cancer cell Homo sapiens
-
2.8.2.4 MCF-7 cell estrogen sulfotransferase is significantly more active in the normal breast cell than in the cancer cell Homo sapiens
-
2.8.2.4 MDA-MB-231 cell
-
Homo sapiens
-
2.8.2.4 T-47D cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.4 3'-phosphoadenylyl sulfate + estradiol SULT1E1 acts at nanomolar concentration of estradiol. SULT1A1 is active at micromolar concentration of estradiol and has an affinity 300fold lower than SULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
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Subunits

EC Number Subunits Comment Organism
2.8.2.4 dimer
-
Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.8.2.4 EST
-
Homo sapiens
2.8.2.4 estrogen sulfotransferase
-
Homo sapiens
2.8.2.4 SULT1A1 active in breast cancer cells Homo sapiens
2.8.2.4 SULT1E1 active in normal breast cells Homo sapiens

Expression

EC Number Organism Comment Expression
2.8.2.4 Homo sapiens SULT expression in breast cancer cells can be stimulated by promegestone, SULT1E1 expression can be controlled by progesterone during the menstrual cycle and during early pregnancy up