EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.8.2.4 | 3beta-hydroxytibolone | 102% stimulation of activity at 0.0005 mM | Homo sapiens | |
2.8.2.4 | celecoxib | - |
Homo sapiens | |
2.8.2.4 | medrogestone | 85% stimulation of activity at 0.0005 mM | Homo sapiens | |
2.8.2.4 | nomegestrol acetate | 42% stimulation of activity at 0.0005 mM | Homo sapiens | |
2.8.2.4 | Promegestone | 31% stimulation of activity at 0.0005 mM | Homo sapiens | |
2.8.2.4 | quercetin | - |
Homo sapiens | |
2.8.2.4 | resveratrol | - |
Homo sapiens | |
2.8.2.4 | tibolone | 41% stimulation of activity at 0.0005 mM | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.8.2.4 | resveratrol | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.8.2.4 | cytosol | - |
Homo sapiens | 5829 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.8.2.4 | 35000 | - |
SULT1E1 | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.8.2.4 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.8.2.4 | breast cancer cell | - |
Homo sapiens | - |
2.8.2.4 | Human-7 cell | - |
Homo sapiens | - |
2.8.2.4 | mammary gland | estrogen sulfotransferase is significantly more active in the normal breast cell than in the cancer cell | Homo sapiens | - |
2.8.2.4 | MCF-7 cell | estrogen sulfotransferase is significantly more active in the normal breast cell than in the cancer cell | Homo sapiens | - |
2.8.2.4 | MDA-MB-231 cell | - |
Homo sapiens | - |
2.8.2.4 | T-47D cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.8.2.4 | 3'-phosphoadenylyl sulfate + estradiol | SULT1E1 acts at nanomolar concentration of estradiol. SULT1A1 is active at micromolar concentration of estradiol and has an affinity 300fold lower than SULT1E1 | Homo sapiens | adenosine 3',5'-bisphosphate + estradiol 3-sulfate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.8.2.4 | dimer | - |
Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.8.2.4 | EST | - |
Homo sapiens |
2.8.2.4 | estrogen sulfotransferase | - |
Homo sapiens |
2.8.2.4 | SULT1A1 | active in breast cancer cells | Homo sapiens |
2.8.2.4 | SULT1E1 | active in normal breast cells | Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
2.8.2.4 | Homo sapiens | SULT expression in breast cancer cells can be stimulated by promegestone, SULT1E1 expression can be controlled by progesterone during the menstrual cycle and during early pregnancy | up |