BRENDA - Enzyme Database

16alpha-hydroxyestrone inhibits estrogen sulfotransferase activity in human liver cancer cells

Campisi, I.; Granata, O.M.; Cocciadiferro, L.; Calabro, M.; Polito, L.M.; Carruba, G.; Ann. N. Y. Acad. Sci. 1155, 237-241 (2009) View publication on PubMed

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.4
16alpha-hydroxyestrone
maximum inhibition at 100 nM
Homo sapiens
2.8.2.4
ICI 182,720
produces a marked decrease (over 50%) of EST activity with respect to untreated control cell cultures at 24 h
Homo sapiens
2.8.2.4
tamoxifen
weak inhibition
Homo sapiens
Organism
EC Number
Organism
UniProt
Commentary
Textmining
2.8.2.4
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
Hep-G2 cell
-
Homo sapiens
-
2.8.2.4
hepatocarcinoma cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
2.8.2.4
3'-phosphoadenylyl sulfate + estradiol
-
701709
Homo sapiens
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
?
Synonyms
EC Number
Synonyms
Commentary
Organism
2.8.2.4
EST
-
Homo sapiens
2.8.2.4
estrogen sulfotransferase
-
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.4
16alpha-hydroxyestrone
maximum inhibition at 100 nM
Homo sapiens
2.8.2.4
ICI 182,720
produces a marked decrease (over 50%) of EST activity with respect to untreated control cell cultures at 24 h
Homo sapiens
2.8.2.4
tamoxifen
weak inhibition
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
Hep-G2 cell
-
Homo sapiens
-
2.8.2.4
hepatocarcinoma cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
2.8.2.4
3'-phosphoadenylyl sulfate + estradiol
-
701709
Homo sapiens
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
?