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Literature summary extracted from

  • Wu, G.; Bazer, F.W.; Davis, T.A.; Kim, S.W.; Li, P.; Marc Rhoads, J.; Carey Satterfield, M.; Smith, S.B.; Spencer, T.E.; Yin, Y.
    Arginine metabolism and nutrition in growth, health and disease (2009), Amino Acids, 37, 153-168.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.88 N-acetylglutamate
-
Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.88 ornithine inhibits only the short enzyme form Mammalia
1.14.13.39 dimethylarginine
-
Mammalia
1.14.13.39 Ng-monomethy-L-arginine
-
Mammalia

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.39 additional information
-
additional information Km-value for arginine about 0.003-0.02 mM Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.39 cytoplasm
-
Mammalia 5737
-
1.14.13.39 mitochondrion
-
Mammalia 5739
-
1.14.13.39 nucleus
-
Mammalia 5634
-
1.14.13.39 plasma membrane
-
Mammalia 5886
-
1.14.13.39 rough endoplasmic reticulum
-
Mammalia 5791
-
3.5.3.1 extracellular
-
Mammalia
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.13.39 Ca2+ dependent, NOS1 and NOS3 Mammalia

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.88 Mammalia
-
-
-
1.14.13.39 Mammalia
-
-
-
3.5.3.1 Capra capra
-
-
-
3.5.3.1 Mammalia
-
-
-
3.5.3.1 no activity in Sus scrofa
-
in enterocytes of suckling piglets or in rapidly growing porcine placentae
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.88 additional information other cell types express long-form Mammalia
-
1.2.1.88 small intestine short isoform Mammalia
-
1.14.13.39 endothelial cell NOS3 Mammalia
-
1.14.13.39 macrophage NOS2 Mammalia
-
1.14.13.39 neuronal cell line NOS1 Mammalia
-
3.5.3.1 allantoic fluid
-
Capra capra
-
3.5.3.1 endothelial cell type I Mammalia
-
3.5.3.1 enterocyte type I, postweaning mammals Mammalia
-
3.5.3.1 hepatocyte type I Mammalia
-
3.5.3.1 intestine intesintal lumen Mammalia
-
3.5.3.1 macrophage type I Mammalia
-
3.5.3.1 mammary epithelial cell type I Mammalia
-
3.5.3.1 additional information type II in mitochondria-containing extrahepatic cells Mammalia
-
3.5.3.1 neuronal cell line type II Mammalia
-
3.5.3.1 plasma
-
Mammalia
-
3.5.3.1 wound fluid
-
Mammalia
-

Subunits

EC Number Subunits Comment Organism
1.14.13.39 dimer
-
Mammalia

Synonyms

EC Number Synonyms Comment Organism
1.2.1.88 P5C synthase
-
Mammalia
1.2.1.88 pyrroline-5-carboxylate synthase two isoforms: short form and long form Mammalia
1.14.13.39 nitric-oxide synthase
-
Mammalia
1.14.13.39 NOS1 isoform1 Mammalia
1.14.13.39 NOS2 isoform2 Mammalia
1.14.13.39 NOS3 isoform3 Mammalia
3.5.3.1 arginase
-
Mammalia
3.5.3.1 arginase
-
Capra capra

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.13.39 additional information
-
Ng-monomethy-L-arginine value about 0.001-0.0016 Mammalia
1.14.13.39 additional information
-
Ng,Ng-dimethylarginine value about 0.001-0.0016 Mammalia

Expression

EC Number Organism Comment Expression
3.5.3.1 Mammalia stimulated by cytokines, inflammatory stimuli, cAMP up

General Information

EC Number General Information Comment Organism
1.2.1.88 physiological function one of three key regulatory enzyme of intestinal citrulline synthesis Mammalia
3.5.3.1 physiological function regulating synthesis of nitric oxide, proline, polyamine Mammalia
3.5.3.1 physiological function regulating synthesis of nitric oxide, proline, polyamine Capra capra