EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.88 | N-acetylglutamate | - |
Mammalia |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.88 | ornithine | inhibits only the short enzyme form | Mammalia | |
1.14.13.39 | dimethylarginine | - |
Mammalia | |
1.14.13.39 | Ng-monomethy-L-arginine | - |
Mammalia |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.13.39 | additional information | - |
additional information | Km-value for arginine about 0.003-0.02 mM | Mammalia |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.13.39 | cytoplasm | - |
Mammalia | 5737 | - |
1.14.13.39 | mitochondrion | - |
Mammalia | 5739 | - |
1.14.13.39 | nucleus | - |
Mammalia | 5634 | - |
1.14.13.39 | plasma membrane | - |
Mammalia | 5886 | - |
1.14.13.39 | rough endoplasmic reticulum | - |
Mammalia | 5791 | - |
3.5.3.1 | extracellular | - |
Mammalia | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.39 | Ca2+ | dependent, NOS1 and NOS3 | Mammalia |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.88 | Mammalia | - |
- |
- |
1.14.13.39 | Mammalia | - |
- |
- |
3.5.3.1 | Capra capra | - |
- |
- |
3.5.3.1 | Mammalia | - |
- |
- |
3.5.3.1 | no activity in Sus scrofa | - |
in enterocytes of suckling piglets or in rapidly growing porcine placentae | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.1.88 | additional information | other cell types express long-form | Mammalia | - |
1.2.1.88 | small intestine | short isoform | Mammalia | - |
1.14.13.39 | endothelial cell | NOS3 | Mammalia | - |
1.14.13.39 | macrophage | NOS2 | Mammalia | - |
1.14.13.39 | neuronal cell line | NOS1 | Mammalia | - |
3.5.3.1 | allantoic fluid | - |
Capra capra | - |
3.5.3.1 | endothelial cell | type I | Mammalia | - |
3.5.3.1 | enterocyte | type I, postweaning mammals | Mammalia | - |
3.5.3.1 | hepatocyte | type I | Mammalia | - |
3.5.3.1 | intestine | intesintal lumen | Mammalia | - |
3.5.3.1 | macrophage | type I | Mammalia | - |
3.5.3.1 | mammary epithelial cell | type I | Mammalia | - |
3.5.3.1 | additional information | type II in mitochondria-containing extrahepatic cells | Mammalia | - |
3.5.3.1 | neuronal cell line | type II | Mammalia | - |
3.5.3.1 | plasma | - |
Mammalia | - |
3.5.3.1 | wound fluid | - |
Mammalia | - |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.14.13.39 | dimer | - |
Mammalia |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.1.88 | P5C synthase | - |
Mammalia |
1.2.1.88 | pyrroline-5-carboxylate synthase | two isoforms: short form and long form | Mammalia |
1.14.13.39 | nitric-oxide synthase | - |
Mammalia |
1.14.13.39 | NOS1 | isoform1 | Mammalia |
1.14.13.39 | NOS2 | isoform2 | Mammalia |
1.14.13.39 | NOS3 | isoform3 | Mammalia |
3.5.3.1 | arginase | - |
Mammalia |
3.5.3.1 | arginase | - |
Capra capra |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.13.39 | additional information | - |
Ng-monomethy-L-arginine | value about 0.001-0.0016 | Mammalia | |
1.14.13.39 | additional information | - |
Ng,Ng-dimethylarginine | value about 0.001-0.0016 | Mammalia |
EC Number | Organism | Comment | Expression |
---|---|---|---|
3.5.3.1 | Mammalia | stimulated by cytokines, inflammatory stimuli, cAMP | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.2.1.88 | physiological function | one of three key regulatory enzyme of intestinal citrulline synthesis | Mammalia |
3.5.3.1 | physiological function | regulating synthesis of nitric oxide, proline, polyamine | Mammalia |
3.5.3.1 | physiological function | regulating synthesis of nitric oxide, proline, polyamine | Capra capra |