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Literature summary extracted from

  • Shi, Y.; Cheng, D.
    Beyond triglyceride synthesis: The dynamic functional roles of MGAT and DGAT enzymes in energy metabolism (2009), Am. J. Physiol. Endocrinol. Metab., 297, E10-8.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.22 medicine selective inhibition may provide a novel treatment for obesity and its related metabolic complications, defective triacylglycerol synthesis and storage can lead to severe insulin resistance, excess triacylglycerol accumulation leads to obesity, ectopic storage in nonadipose tissues such as liver and skeletal muscle is associated with insulin resistance Mammalia

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.22 additional information MGAT2 knockout mice exhibit a reduction of metabolic efficiency and increased thermogenic energy expenditure when fed a high-fat diet, they are protected from developing obesity, fatty liver, hyperlipidemia, and glucose intolerance despite chronic high-fat feeding Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.22 endoplasmic reticulum
-
 Mammalia 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.22 monoacylglycerol + fatty acyl-CoA Mammalia monoacylglycerol pathway predominates in enterocytes after feeding, when large amounts of 2-monoacylglycerols and fatty acids are released from the digestion of dietary lipids diacylglycerol + CoA
-
 ?
2.3.1.22 monoacylglycerol + fatty acyl-CoA Mammalia monoacylglycerol pathway predominates in enterocytes after feeding, when large amounts of 2-monoacylglycerols and fatty acids are released from the digestion of dietary lipids, also active in adipose tissue diacylglycerol + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.22 Mammalia
-
-
-
2.3.1.22 Mammalia
-
 higher mammals, humans, not in rodents
-
2.3.1.22 no activity in Rodentia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.22 adipose tissue
-
 Mammalia
-
2.3.1.22 adipose tissue MGAT1 Mammalia
-
2.3.1.22 enterocyte uptake of monoacylglycerol and fatty acids, resynthesized into triacylglycerols, packaged into chylomicrons, and secreted into circulation Mammalia
-
2.3.1.22 kidney
-
 Mammalia
-
2.3.1.22 kidney MGAT1 Mammalia
-
2.3.1.22 small intestine highest expression in midgut Mammalia
-
2.3.1.22 small intestine MGAT2, MGAT3 Mammalia
-
2.3.1.22 stomach MGAT1 Mammalia
-
2.3.1.22 stomach most prominent expression Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.22 monoacylglycerol + fatty acyl-CoA monoacylglycerol pathway predominates in enterocytes after feeding, when large amounts of 2-monoacylglycerols and fatty acids are released from the digestion of dietary lipids Mammalia diacylglycerol + CoA
-
 ?
2.3.1.22 monoacylglycerol + fatty acyl-CoA monoacylglycerol pathway predominates in enterocytes after feeding, when large amounts of 2-monoacylglycerols and fatty acids are released from the digestion of dietary lipids, also active in adipose tissue Mammalia diacylglycerol + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.22 MGAT
-
 Mammalia
2.3.1.22 MGAT1
-
 Mammalia
2.3.1.22 Mgat2 activity is mirroring dietary fat absorption Mammalia
2.3.1.22 MGAT3 small intestine, only in higher mammals and humans, not in rodents, more homology with DGAT2 than with other MGAT isoforms Mammalia
2.3.1.22 monoacylglycerol acyltransferase
-
 Mammalia

Expression

EC Number Organism Comment Expression
2.3.1.22 Mammalia diabetes, obesity, and lactation induce liver monoacylglycerol acyltransferase activity in rodents that is correlated with increased fat absorption up

General Information

EC Number General Information Comment Organism
2.3.1.22 malfunction mice with targeted inactivation of the MGAT2 gene exhibit a delay in dietary fat absorption, however, in contrast to knockout mice that absorb normal quantities of fat Mammalia
2.3.1.22 metabolism monoacylglycerol pathway followed by diacylglycerol acyltransferase activity to produce triacylglycerol Mammalia
2.3.1.22 metabolism monoacylglycerol pathway is followed by diacylglycerol acyltransferase activity to produce triacylglycerol Mammalia
2.3.1.22 physiological function besides being the substrates for monoacylglycerol acyltransferase, monoacylglycerols, especially 2-acylglycerol, function as endogenous ligand for endocannaboid receptors, thus stimulating appetite Mammalia
2.3.1.22 physiological function involved in functions such as intestinal fat absorption, lipoprotein assembly, adipose tissue formation, signal transduction, satiety, lactation, for example by the modulation of intracellular levels of monoacylglycerols and diacylglycerols Mammalia
2.3.1.22 physiological function involved in functions such as intestinal fat absorption, lipoprotein assembly, adipose tissue formation, signal transduction, satiety, lactation, for example by the modulation of intracellular levels of monoacylglycerols and diacylglycerols, 2-acylglycerol functions as endogenous ligand for endocannaboid receptors, stimulating appetite Mammalia
2.3.1.22 physiological function involved in functions such as intestinal fat absorption, lipoprotein assembly, adipose tissue formation, signal transduction, satiety, lactation, for example by the modulation of intracellular levels of monoacylglycerols and diacylglycerols, 2-acylglycerol functions as endogenous ligand for endocannaboid receptors, stimulating apppetite Mammalia