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Literature summary extracted from

  • Kim, S.H.; Kang, Y.M.; Kim, S.H.; Cho, B.Y.; Ye, Y.M.; Hur, G.Y.; Park, H.S.
    Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria (2009), Allergy, 64, 213-221.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.8 expressed in HMC-1 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.8 additional information the A939G polymorphism is significantly associated with the aspirin intolerant chronic urticaria phenotype, while no association is found with the C314T polymorphism, the 939A allele gives lower levels of HNMT mRNA stability, HNMT protein expression, and HNMT enzymatic activity and higher histamine release than the 939G allele, patients with the 939A allele have lower HNMT activity in red blood cell lysates and higher histamine release from their basophils Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.8 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.8 S-adenosyl-L-methionine + histamine
-
 Homo sapiens S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.8 HNMT
-
 Homo sapiens