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Literature summary extracted from

  • Maurice, H.; Tuarira, E.; Mwambete, K.
    Virtual high screening throughput and design of 14alpha-lanosterol demethylase inhibitors against Mycobacterium tuberculosis (2009), Afr. J. Biotechnol., 8, 3072-3078.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.154 clomiphene interacts with heme, is less potent than azoles Mycobacterium tuberculosis
1.14.14.154 fluconazole
-
 Mycobacterium tuberculosis
1.14.14.154 glafenine interacts with heme, shows no potency which may arise from its hydrophilic nature which lower its up-take and capacity to reach the target enzyme Mycobacterium tuberculosis
1.14.14.154 ketoconazole residues lining the ketoconazole pocket include Ala397 and Ala398, Arg389 and Arg393, Asp377, Glu308, Gly390, Ile401, Leu311 and Leu315, Lys312, Phe387, Pro386, Trp382 and Trp384 Mycobacterium tuberculosis
1.14.14.154 miconazole
-
 Mycobacterium tuberculosis
1.14.14.154 additional information the aromatic moieties of drugs where aligning to phenylalanine and tyrosine residues that lines the hydrophobic part of the binding pocket which is itself generally hydrophobic Mycobacterium tuberculosis
1.14.14.154 N-{2-[4-(acetylamino)phenyl]ethyl}-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamide interacts with heme Mycobacterium tuberculosis
1.14.14.154 rottlerin interacts with heme Mycobacterium tuberculosis
1.14.14.154 SPSM1 interacts with heme Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Mycobacterium tuberculosis P9WPP9
-
-
1.14.14.154 Mycobacterium tuberculosis H37Rv P9WPP9
-
-

Synonyms

EC Number Synonyms Comment Organism
1.14.14.154 14alpha-lanosterol demethylase
-
 Mycobacterium tuberculosis
1.14.14.154 CYP51
-
 Mycobacterium tuberculosis