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Literature summary extracted from

  • Merida, I.; Avila-Flores, A.; Garcia, J.; Merino, E.; Almena, M.; Torres-Ayuso, P.
    Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression (2009), Adv. Enzyme Regul., 49, 174-188.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.107 cholesterol DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such cholesterol Homo sapiens
2.7.1.107 cholesterol DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such cholesterol Mus musculus
2.7.1.107 P53 p53 activates DGKalpha in response to DNA damage Homo sapiens
2.7.1.107 P53 p53 activates DGKalpha in response to DNA damage Mus musculus
2.7.1.107 phosphatidylethanolamine DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such as phosphatidylethanolamine Homo sapiens
2.7.1.107 phosphatidylethanolamine DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such as phosphatidylethanolamine Mus musculus

General Stability

EC Number General Stability Organism
2.7.1.107 activation of tyrosine kinases is required for membrane stabilization of DGKalpha, phosphorylation of DGKalpha at Tyr335 appears to be essential for membrane localization Homo sapiens
2.7.1.107 activation of tyrosine kinases is required for membrane stabilization of DGKalpha, phosphorylation of DGKalpha at Tyr335 appears to be essential for membrane localization Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.107 cytosol DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function Homo sapiens 5829
-
2.7.1.107 cytosol DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function Mus musculus 5829
-
2.7.1.107 membrane DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function Homo sapiens 16020
-
2.7.1.107 membrane DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function Mus musculus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.107 Ca2+ Ca2+ requirement in DGKalpha activation Homo sapiens
2.7.1.107 Ca2+ Ca2+ requirement in DGKalpha activation Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Homo sapiens P23743
-
-
2.7.1.107 Mus musculus O88673
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 brain high expression Mus musculus
-
2.7.1.107 endothelial cell
-
 Homo sapiens
-
2.7.1.107 endothelial cell
-
 Mus musculus
-
2.7.1.107 heart low expression Mus musculus
-
2.7.1.107 kidney low expression Mus musculus
-
2.7.1.107 liver low expression Mus musculus
-
2.7.1.107 lung high expression Mus musculus
-
2.7.1.107 oligodendrocyte DGKalpha is expressed predominantly in oligodendrocytes Homo sapiens
-
2.7.1.107 oligodendrocyte DGKalpha is expressed predominantly in oligodendrocytes Mus musculus
-
2.7.1.107 spleen high expression Mus musculus
-
2.7.1.107 T-lymphocyte particularly enriched in peripheral T lymphocytes Homo sapiens
-
2.7.1.107 T-lymphocyte particularly enriched in peripheral T lymphocytes Mus musculus
-
2.7.1.107 testis high expression Mus musculus
-
2.7.1.107 thymus particularly enriched in thymus Homo sapiens
-
2.7.1.107 thymus particularly enriched in thymus Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 ATP + 1,2-diacylglycerol
-
 Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacylglycerol
-
 Mus musculus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.107 DGKalpha isoform Homo sapiens
2.7.1.107 DGKalpha isoform Mus musculus
2.7.1.107 diacylglycerol kinase alpha isoform Homo sapiens
2.7.1.107 diacylglycerol kinase alpha isoform Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.107 ATP
-
 Homo sapiens
2.7.1.107 ATP
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.7.1.107 Homo sapiens p53-mediated upregulation of DGKalpha mRNA in human-derived cells, (PPAR)-gamma-dependent DGKalpha upregulation in endothelial cells, DMSO-based differentiation of promyelocytic HL-60 cells into a neutrophilic phenotype correlates with increase in the expression of DGKalpha, DGKalpha expression is upregulated in cancer up
2.7.1.107 Mus musculus p53-mediated upregulation of DGKalpha mRNA in mouse-derived cells, (PPAR)-gamma-dependent DGKalpha upregulation in endothelial cells, DMSO-based differentiation of promyelocytic HL-60 cells into a neutrophilic phenotype correlates with increase in the expression of DGKalpha, DGKalpha expression is upregulated in cancer up

General Information

EC Number General Information Comment Organism
2.7.1.107 physiological function membrane localization of DGKalpha acts as a switch-off signal for Ras activation, mediated by localization to the membrane of Ras-GRP1, DGKalpha is a negative regulator of the T cell activation program, DGKalpha activity is required for optimal chemotactic response of neutrophils, whereas it halts their oxidative burst, DGKalpha is a negative modulator of diacylglycerol signaling, DGKalpha activity modulates the mTOR pathway to prevent cell cycle transition, DGKalpha is an indicator of cell quiescence, DGKalpha is a positive regulator of cell proliferation and migration Homo sapiens
2.7.1.107 physiological function membrane localization of DGKalpha acts as a switch-off signal for Ras activation, mediated by localization to the membrane of Ras-GRP1, DGKalpha is a negative regulator of the T cell activation program, DGKalpha activity is required for optimal chemotactic response of neutrophils, whereas it halts their oxidative burst, DGKalpha is a negative modulator of diacylglycerol signaling, DGKalpha activity modulates the mTOR pathway to prevent cell cycle transition, DGKalpha is an indicator of cell quiescence, DGKalpha is a positive regulator of cell proliferation and migration Mus musculus