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Literature summary extracted from

  • Mochalkin, I.; Miller, J.R.; Narasimhan, L.; Thanabal, V.; Erdman, P.; Cox, P.B.; Prasad, J.V.; Lightle, S.; Huband, M.D.; Stover, C.K.
    Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches (2009), ACS Chem. Biol., 4, 473-483.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.14 2-amino-N,N-dibenzyl-1,3-oxazole-5-carboxamide minimal inhibitory concentration above 64 microg per ml for wild-type, 16 microg per ml for mutant with targeted knock-out of efflux pump tolC and imp gene disruption Escherichia coli
6.3.4.14 2-amino-N,N-dibenzyl-1,3-oxazole-5-carboxamide minimal inhibitory concentration above 64 microg per ml for wild-type, 4 microg per ml for mutant with targeted knock-out of efflux pump acrA Haemophilus influenzae
6.3.4.14 2-amino-N,N-dibenzyl-1,3-oxazole-5-carboxamide minimal inhibitory concentration 8 microg per ml for wild-type, 4 microg per ml for mutant with targeted knock-out of efflux pump acrA Moraxella catarrhalis
6.3.4.14 2-amino-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-(2-methylbenzyl)-1,3-oxazole-5-carboxamide minimal inhibitory concentration above 64 microg per ml for wild-type, 8 microg per ml for mutant with targeted knock-out of efflux pump tolC and imp gene disruption Escherichia coli
6.3.4.14 2-amino-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-(2-methylbenzyl)-1,3-oxazole-5-carboxamide minimal inhibitory concentration above 64 microg per ml for wild-type, 4 microg per ml for mutant with targeted knock-out of efflux pump acrA Haemophilus influenzae
6.3.4.14 2-amino-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-(2-methylbenzyl)-1,3-oxazole-5-carboxamide minimal inhibitory concentration 16 microg per ml for wild-type, 4 microg per ml for mutant with targeted knock-out of efflux pump acrA Moraxella catarrhalis
6.3.4.14 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine minimal inhibitory concentration 16 microg per ml for wild-type, 0.125 microg per ml for mutant with targeted knock-out of efflux pump tolC and imp gene disruption Escherichia coli
6.3.4.14 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine minimal inhibitory concentration 0.125 microg per ml for wild-type, 0.125 microg per ml for mutant with targeted knock-out of efflux pump acrA Haemophilus influenzae
6.3.4.14 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine minimal inhibitory concentration 1 microg per ml for wild-type, 0.5 microg per ml for mutant with targeted knock-out of efflux pump acrA Moraxella catarrhalis

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.14 Escherichia coli P24182
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6.3.4.14 Haemophilus influenzae
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6.3.4.14 Moraxella catarrhalis
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