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Literature summary extracted from

  • Pentzien, A.K.; Meisel, H.
    Transepithelial transport and stability in blood serum of angiotensin-I-converting enzyme inhibitory dipeptides (2008), Z. Naturforsch. C, 63, 451-459.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 L-Ala-L-Trp
-
 Homo sapiens
3.4.15.1 L-Ala-L-Trp
-
 Oryctolagus cuniculus
3.4.15.1 L-Val-L-Phe
-
 Homo sapiens
3.4.15.1 L-Val-L-Phe
-
 Oryctolagus cuniculus
3.4.15.1 L-Val-L-Tyr
-
 Homo sapiens
3.4.15.1 L-Val-L-Tyr
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 angiotensin I + H2O Homo sapiens
-
 angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 angiotensin I + H2O Oryctolagus cuniculus
-
 angiotensin II + L-His-L-Leu
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.5 Homo sapiens
-
-
-
3.4.15.1 Homo sapiens
-
-
-
3.4.15.1 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.5 Caco-2 cell
-
 Homo sapiens
-
3.4.15.1 lung
-
 Oryctolagus cuniculus
-
3.4.15.1 serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.5 L-Ala-L-Pro-4-nitroanilide
-
 Homo sapiens L-Ala-L-Pro + 4-nitroaniline
-
 ?
3.4.15.1 angiotensin I + H2O
-
 Homo sapiens angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 angiotensin I + H2O
-
 Oryctolagus cuniculus angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 hippuryl-L-His-L-Leu + H2O
-
 Homo sapiens hippuric acid + L-His-L-Leu
-
 ?
3.4.15.1 hippuryl-L-His-L-Leu + H2O
-
 Oryctolagus cuniculus hippuric acid + L-His-L-Leu
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.14.5 dipeptidyl aminopeptidase IV
-
 Homo sapiens
3.4.14.5 DPPIV
-
 Homo sapiens
3.4.15.1 ACE
-
 Homo sapiens
3.4.15.1 ACE
-
 Oryctolagus cuniculus
3.4.15.1 angiotensin-I-converting enzyme
-
 Homo sapiens
3.4.15.1 angiotensin-I-converting enzyme
-
 Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.15.1 0.0065
-
 in 0.1 mM sodium borate buffer, 0.3 mM NaCl, pH 8.3, at 37°C Oryctolagus cuniculus L-Ala-L-Trp
3.4.15.1 0.0122
-
 in 0.1 mM sodium borate buffer, 0.3 mM NaCl, pH 8.3, at 37°C Oryctolagus cuniculus L-Val-L-Tyr
3.4.15.1 0.051
-
 in 0.1 mM sodium borate buffer, 0.3 mM NaCl, pH 8.3, at 37°C Oryctolagus cuniculus L-Val-L-Phe