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Literature summary extracted from

  • Garcia, A.A.; Reitsma, P.H.
    VKORC1 and the vitamin K cycle (2008), Vitam. Horm., 78, 23-33.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.17.4.4 expressed in Sf9 insect cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.4 (R)-warfarin
-
 Homo sapiens
1.17.4.4 (S)-warfarin
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.4.4 endoplasmic reticulum
-
 Homo sapiens 5783
-
1.17.4.4 membrane transmembrane protein Homo sapiens 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.17.4.4 18000
-
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.4 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.4 vitamin K 2,3-epoxide + oxidized dithiothreitol
-
 Homo sapiens vitamin K + 1,4-dithiothreitol
-
 ir

Synonyms

EC Number Synonyms Comment Organism
1.17.4.4 vitamin K epoxide reductase complex subunit 1
-
 Homo sapiens
1.17.4.4 VKORC1
-
 Homo sapiens