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Literature summary extracted from

  • Wallin, R.; Wajih, N.; Hutson, S.M.
    VKORC1: a warfarin-sensitive enzyme in vitamin K metabolism and biosynthesis of vitamin K-dependent blood coagulation factors (2008), Vitam. Horm., 78, 227-246.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.17.4.4 expressed in HEK-293 cells Homo sapiens
1.17.4.4 expressed in HEK-293 cells Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.4 calumenin
-
 Homo sapiens
1.17.4.4 calumenin
-
 Rattus norvegicus
1.17.4.4 dicoumarol
-
 Rattus norvegicus
1.17.4.4 dicumarol
-
 Homo sapiens
1.17.4.4 warfarin
-
 Homo sapiens
1.17.4.4 warfarin
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.4 Homo sapiens
-
-
-
1.17.4.4 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol
-
 Homo sapiens vitamin K + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol
-
 Rattus norvegicus vitamin K + oxidized dithiothreitol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.4.4 vitamin K epoxide reductase complex subunit 1
-
 Homo sapiens
1.17.4.4 vitamin K epoxide reductase complex subunit 1
-
 Rattus norvegicus
1.17.4.4 vitamin K-2,3-epoxide reductase
-
 Homo sapiens
1.17.4.4 vitamin K-2,3-epoxide reductase
-
 Rattus norvegicus
1.17.4.4 VKOR
-
 Homo sapiens
1.17.4.4 VKOR
-
 Rattus norvegicus
1.17.4.4 VKORC1
-
 Homo sapiens
1.17.4.4 VKORC1
-
 Rattus norvegicus