Literature summary extracted from

Li, T.; Woods, J.S.
Cloning, expression, and biochemical properties of CPOX4, a genetic variant of coproporphyrinogen oxidase that affects susceptibility to mercury toxicity in humans (2009), Toxicol. Sci., 109, 228-236.

Application

EC Number	Application	Comment	Organism
1.3.3.3	medicine	natural polymorphism A814C leading to mutation N272H results in twofold decrease in affinity for coproporphyrinogen-III. Specific activity in liver samples is 40-50% lower than in wild-type, mutation may predispose to impaired heme biosynthesis	Homo sapiens

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.3.3.3	N272H	natural polymorphism, twofold decrease in affinity for coproporphyrinogen-III. Specific activity in liver samples is 40-50% lower than in wild-type	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.3.3.3	Hg2+	acts comparably on wild-type and mutant N272H	Homo sapiens

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.3.3.3	0.00029	-	Coproporphyrinogen-III	wild-type, pH 7.2, 37°C	Homo sapiens
1.3.3.3	0.00054	-	Coproporphyrinogen-III	mutant N272H, pH 7.2, 37°C	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.3.3.3	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.3.3.3	liver	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.3.3.3	coproporphyrinogen-III + O2 + 2 H+	-	Homo sapiens	protoporphyrinogen-IX + 2 CO2 + 2 H2O	-	?

Turnover Number [1/s]

EC Number	Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
1.3.3.3	0.6	-	Coproporphyrinogen-III	mutant N272H, pH 7.2, 37°C	Homo sapiens
1.3.3.3	1.8	-	Coproporphyrinogen-III	wild-type, pH 7.2, 37°C	Homo sapiens

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Release 2023.1 (January 2023)