Literature summary extracted from

Jain, M.; Tilak, A.R.; Upadhyay, R.; Kumar, A.; Mittal, B.
Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer (2008), Toxicol. Appl. Pharmacol., 230, 247-251.

Application

EC Number	Application	Comment	Organism
3.3.2.9	medicine	patients with exon 3 genotypes (Tyr113His, His113His) and 113His allele are at risk of squamous cell esophageal cancer, none of haplotype combinations of exon 3 (Y113H) and exon 4 (H139R) polymorphisms show modulation of risk for squamous cell esophageal cancer	Homo sapiens

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.3.2.9	H139R	the mutant exhibits low risk for squamous cell esophageal cancer	Homo sapiens
3.3.2.9	Y113H	the mutation is associated with higher risk of squamous cell esophageal cancer	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.3.2.9	microsome	-	Homo sapiens	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.3.2.9	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.3.2.9	cis-stilbene oxide + H2O	-	Homo sapiens	(1R,2R)-1,2-diphenylethane-1,2-diol	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.3.2.9	EPHX1	-	Homo sapiens

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Release 2023.1 (January 2023)