Literature summary extracted from

Piekielko-Witkowska, A.; Master, A.; Wojcicka, A.; Boguslawska, J.; Brozda, I.; Tanski, Z.; Nauman, A.
Disturbed expression of type 1 iodothyronine deiodinase splice variants in human renal cancer (2009), Thyroid, 19, 1105-1113.

Application

EC Number	Application	Comment	Organism
1.21.99.4	medicine	expression and alternative splicing of DIO mRNA is disturbed in renal cancer, possibly due to changes in expression of splicing factors SF2/ASF and hnRNPA1	Homo sapiens

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.21.99.4	different splicing variants of DOI1 are cloned into the vector pGEM-T for sequencing, 11 variants are identified	Homo sapiens

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
1.21.99.4	selenium	-	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.21.99.4	L-thyroxine + AH2	Homo sapiens	activation and deactivation of thyroid hormone	3,5,3'-triiodo-L-thyronine + iodide + A + H+	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.21.99.4	Homo sapiens	P49895	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.21.99.4	kidney	-	Homo sapiens	-
1.21.99.4	renal cell carcinoma cell	ccRCC	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.21.99.4	L-thyroxine + AH2	activation and deactivation of thyroid hormone	Homo sapiens	3,5,3'-triiodo-L-thyronine + iodide + A + H+	-	r

Synonyms

EC Number	Synonyms	Comment	Organism
1.21.99.4	DIO1	-	Homo sapiens
1.21.99.4	type 1 iodothyronine deiodinase	-	Homo sapiens

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Release 2023.1 (January 2023)