Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Maeshiro, K.; Takamori, S.; Mifune, H.; Matsuo, T.; Kimura, N.Y.; Honda, J.; Shirouzu, K.
    Changes in A-type natriuretic peptide and its receptors induced by a neutral endopeptidase inhibitor in a rat model of sepsis (2008), Surg. Today, 38, 130-134.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.11 pharmacology inhibitor thiorphan might be effective for reducing elevated A-type natriuretic peptide levels in sepsis. Plasma and lung A-type natriuretic peptide levels in rats treated with lipopolysaccharide are significantly higher than those in the control group, but are significantly decreased by thiorphan administration. Natriuretic peptide receptor-A mRNA levels do not differ significantly among the groups. Natriuretic peptide receptor-C mRNA levels in animals treated with lipopolysaccharide plus thiorphan group are significantly higher than those in the other groups Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.11 thiorphan plasma and lung A-type natriuretic peptide levels in rats treated with lipopolysaccharide are significantly higher than those in the control group, but are significantly decreased by thiorphan administration. Natriuretic peptide receptor-A mRNA levels do not differ significantly among the groups. Natriuretic peptide receptor-C mRNA levels in animals treated with lipopolysaccharide plus thiorphan group are significantly higher than those in the other groups Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.11 Rattus norvegicus
-
-
-