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Literature summary extracted from

  • Gillio-Meina, C.; Phang, S.H.; Mather, J.P.; Knight, B.S.; Kennedy, T.G.
    Expression patterns and role of prostaglandin-endoperoxide synthases, prostaglandin E synthases, prostacyclin synthase, prostacyclin receptor, peroxisome proliferator-activated receptor delta and retinoid x receptor alpha in rat endometrium during artificially-induced decidualization (2009), Reproduction, 137, 537-552.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.4 cytoplasm
-
 Rattus norvegicus 5737
-
5.3.99.4 nucleus
-
 Rattus norvegicus 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.99.1 72000
-
 isozyme PTGS-2 Rattus norvegicus
5.3.99.4 56500
-
 determined by SDS-PAGE and Western Blot analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.4 Prostaglandin H2 Rattus norvegicus
-
 Prostaglandin I2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.1 Rattus norvegicus P35355
-
-
1.14.99.1 Rattus norvegicus Q63921
-
-
5.3.99.4 Rattus norvegicus Q62969 female Sprague-Dawley rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.1 uterine endometrium
-
 Rattus norvegicus
-
5.3.99.4 endometrium
-
 Rattus norvegicus
-
5.3.99.4 glandular epithelium
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 Prostaglandin H2
-
 Rattus norvegicus Prostaglandin I2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.1 PG-endoperoxide synthetase
-
 Rattus norvegicus
1.14.99.1 PTGS-1 isoform Rattus norvegicus
1.14.99.1 PTGS-2 isoform Rattus norvegicus
5.3.99.4 PGI synthase
-
 Rattus norvegicus
5.3.99.4 prostacyclin synthase
-
 Rattus norvegicus
5.3.99.4 Ptgis
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.14.99.1 Rattus norvegicus isozyme Ptgs2 transcript level significantly increases at 2 and 4 h after the deciduogenic stimulus with sesame oil is given, and the levels return to prestimulated levels at 8, 16, and 32 h. In contrast to isoform PTGS1 protein levels, PTGS2 protein is significantly higher at 8 h and remains elevated at 16 and 32 h. PTGS2 protein levels are significantly higher in stimulated endometrium at 8 and 32 h than in nonstimulated endometrium up