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Literature summary extracted from
- Structural bioinformatics of Vibrio cholerae aminopeptidase A (PepA) monomer (2009), Protein Pept. Lett., 16, 36-45.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.11.1 | expressed in Escherichia coli | Vibrio cholerae |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.1 | Zn2+ | - |
Vibrio cholerae |  |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.1 | Mn2+ | PepA requires Mn2+ for full activity, 2 Mn2+ ions occupy the metal binding site | Vibrio cholerae | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.1 | 54620 | - |
calculated from amino acid sequence | Vibrio cholerae |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.1 | additional information | Vibrio cholerae | PepA functions as a transcriptional repressor in regulatory cascade that controls virulence gene expression in Vibrio cholerae | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.11.1 | Vibrio cholerae | P0C6E1 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.1 | L-Leu-p-nitroanilide + H2O | - |
Vibrio cholerae | L-Leu + p-nitroaniline | - |
? | |
| 3.4.11.1 | additional information | PepA functions as a transcriptional repressor in regulatory cascade that controls virulence gene expression in Vibrio cholerae | Vibrio cholerae | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.11.1 | homohexamer | - |
Vibrio cholerae |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.11.1 | aminopeptidase A | - |
Vibrio cholerae |
| 3.4.11.1 | LAP | - |
Vibrio cholerae |
| 3.4.11.1 | PepA | - |
Vibrio cholerae |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 3.4.11.1 | Vibrio cholerae | calculated from amino acid sequence | - |
6.4 |
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Release 2023.1 (January 2023)
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