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Literature summary extracted from

  • Klapacz, J.; Meira, L.B.; Luchetti, D.G.; Calvo, J.A.; Bronson, R.T.; Edelmann, W.; Samson, L.D.
    O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo (2009), Proc. Natl. Acad. Sci. USA, 106, 576-581.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.11.1 molecular biology Exo1 plays an important role in the induction of apoptosis by unrepaired O6-methylguanines Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.11.1 additional information Mus musculus Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals ?
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 ?
3.1.11.1 additional information Mus musculus C57/BL6J Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.11.1 Mus musculus
-
 C57BL/6J mice
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3.1.11.1 Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.11.1 bone marrow
-
 Mus musculus
-
3.1.11.1 MEF cell
-
 Mus musculus
-
3.1.11.1 spleen
-
 Mus musculus
-
3.1.11.1 thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.11.1 additional information Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals Mus musculus ?
-
 ?
3.1.11.1 additional information Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals Mus musculus C57/BL6J ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.11.1 Exo1
-
 Mus musculus
3.1.11.1 exonuclease 1
-
 Mus musculus