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Literature summary extracted from

  • Schupp, M.; Lefterova, M.I.; Janke, J.; Leitner, K.; Cristancho, A.G.; Mullican, S.E.; Qatanani, M.; Szwergold, N.; Steger, D.J.; Curtin, J.C.; Kim, R.J.; Suh, M.J.; Suh, M.; Albert, M.R.; Engeli, S.; Gudas, L.J.; Lazar, M.A.
    Retinol saturase promotes adipogenesis and is downregulated in obesity (2009), Proc. Natl. Acad. Sci. USA, 106, 1105-1110.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.99.23 peroxisome proliferator activated receptor gamma PPARgamma Mus musculus
1.3.99.23 peroxisome proliferator activated receptor gamma PPARgamma Homo sapiens
1.3.99.23 thiazolidinedione
-
 Mus musculus
1.3.99.23 thiazolidinedione
-
 Homo sapiens

Application

EC Number Application Comment Organism
1.3.99.23 medicine RetSat plays an important role in the biology of adipocytes, where it favors normal differentiation, yet is reduced in the obese state, RetSat is thus a novel target for therapeutic intervention in metabolic disease Mus musculus
1.3.99.23 medicine RetSat plays an important role in the biology of adipocytes, where it favors normal differentiation, yet is reduced in the obese state, RetSat is thus a novel target for therapeutic intervention in metabolic disease Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.99.23
-
 Mus musculus
1.3.99.23
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.3.99.23 E34A mutant, mutation within the highly conserved region of the dinucleotide-binding motif Mus musculus
1.3.99.23 E34A mutant, mutation within the highly conserved region of the dinucleotide-binding motif Homo sapiens
1.3.99.23 E96A mutant, mutation within the highly conserved region of the dinucleotide-binding motif Mus musculus
1.3.99.23 E96A mutant, mutation within the highly conserved region of the dinucleotide-binding motif Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.99.23 60000
-
 determined by SDS-PAGE and Western Blot analysis Mus musculus
1.3.99.23 60000
-
 determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.99.23 all-trans-retinol + reduced acceptor Mus musculus
-
 all-trans-13,14-dihydroretinol + acceptor
-
 ?
1.3.99.23 all-trans-retinol + reduced acceptor Homo sapiens
-
 all-trans-13,14-dihydroretinol + acceptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.99.23 Homo sapiens
-
-
-
1.3.99.23 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.99.23 3T3-L1 cell
-
 Mus musculus
-
1.3.99.23 adipocyte
-
 Mus musculus
-
1.3.99.23 adipocyte
-
 Homo sapiens
-
1.3.99.23 BOSC-23 cell
-
 Homo sapiens
-
1.3.99.23 HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.99.23 all-trans-retinol + reduced acceptor
-
 Mus musculus all-trans-13,14-dihydroretinol + acceptor
-
 ?
1.3.99.23 all-trans-retinol + reduced acceptor
-
 Homo sapiens all-trans-13,14-dihydroretinol + acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.99.23 retinol saturase
-
 Mus musculus
1.3.99.23 retinol saturase
-
 Homo sapiens
1.3.99.23 RetSat
-
 Mus musculus
1.3.99.23 RetSat
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.99.23 FAD FAD/NAD dinucleotide binding motif Mus musculus
1.3.99.23 FAD FAD/NAD dinucleotide binding motif Homo sapiens
1.3.99.23 NAD+ FAD/NAD dinucleotide binding motif Mus musculus
1.3.99.23 NAD+ FAD/NAD dinucleotide binding motif Homo sapiens

Expression

EC Number Organism Comment Expression
1.3.99.23 Mus musculus in adipocytes down-regulated in obesity down
1.3.99.23 Homo sapiens in adipocytes down-regulated in obesity down
1.3.99.23 Mus musculus incubation of mature adipocytes with pioglitazone or the non-thiazolidinedione ligand GW7845 increases RetSat mRNA expression, peroxisome proliferator activated receptor gamma, PPARgamma, is required for RetSat expression in mature adipocytes up
1.3.99.23 Homo sapiens incubation of mature adipocytes with pioglitazone or the non-thiazolidinedione ligand GW7845 increases RetSat mRNA expression, peroxisome proliferator activated receptor gamma, PPARgamma, is required for RetSat expression in mature adipocytes up