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Literature summary extracted from

  • Singh, R.; Lemire, J.; Mailloux, R.J.; Chenier, D.; Hamel, R.; Appanna, V.D.
    An ATP and oxalate generating variant tricarboxylic acid cycle counters aluminum toxicity in pseudomonas fluorescens (2009), PLoS ONE, 4, e7344.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.17 Al3+ modulation of AGODH activity, exposure of the Al-challenged cells to a control medium results in a dramatic decrease in the activity of AGODH, in contrast, control cells incubated in an Al-enriched medium display an intense activity band, AGODH may be pivotal to the adaptation of Pseudomonas fluorescens to aluminium toxicity Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.17 glyoxylate + CoA + NADP+ Pseudomonas fluorescens
-
 oxalyl-CoA + NADPH + H+
-
 r
1.2.1.17 additional information Pseudomonas fluorescens modified TCA cycle with diminished efficacy in NADH production and decreased CO2-evolving capacity, orchestrates the synthesis of oxalate, NADPH and ATP, ingredients pivotal to the survival in an aluminium environment ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.17 Pseudomonas fluorescens
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.17 additional information
-
 upregulation of acylating glyoxylate dehydrogenase leads to an enhanced synthesis of oxalate, a dicarboxylic acid involved in the immobilization of aluminum, exposure of the Al-challenged cells to a control medium results in a dramatic decrease in the activity of AGODH, in contrast, control cells incubated in an Al-enriched medium display an intense activity band Pseudomonas fluorescens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.17 glyoxylate + CoA + NADP+
-
 Pseudomonas fluorescens oxalyl-CoA + NADPH + H+
-
 r
1.2.1.17 additional information modified TCA cycle with diminished efficacy in NADH production and decreased CO2-evolving capacity, orchestrates the synthesis of oxalate, NADPH and ATP, ingredients pivotal to the survival in an aluminium environment Pseudomonas fluorescens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.17 acylating glyoxylate dehydrogenase
-
 Pseudomonas fluorescens
1.2.1.17 AGODH
-
 Pseudomonas fluorescens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.17 NADP+
-
 Pseudomonas fluorescens