Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bondareva, A.; Downey, C.M.; Ayres, F.; Liu, W.; Boyd, S.K.; Hallgrimsson, B.; Jirik, F.R.
    The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells (2009), PLoS ONE, 4, e5620.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.4.3.13 medicine LOX inhibition might be useful in metastasis prevention, metastasis model and drug administration study in mice, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.13 2-Aminopropionitrile i.e. BAPN, is an irreversible inhibitor of LOX, involved in regulating the metastatic colonization potential of the human breast cancer cell line MDAMB-231 Homo sapiens
1.4.3.13 beta-aminopropionitrile a specific lysyl oxidase inhibitor, diminishes the metastatic colonization potential of circulating breast cancer cells, detailed overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.13 extracellular
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.13 Homo sapiens
-
-
-
1.4.3.13 Homo sapiens P28300
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.13 breast cancer cell circulating Homo sapiens
-
1.4.3.13 MDA-MB-231 cell
-
 Homo sapiens
-
1.4.3.13 MDA-MB-231-Luc2 cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
1.4.3.13 LOX
-
 Homo sapiens
1.4.3.13 lysyl oxidase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.4.3.13 additional information lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells, detailed overview. LOX inhibition might be useful in metastasis prevention Homo sapiens
1.4.3.13 physiological function the extracellular matrix remodeling enzyme has a role in promoting breast cancer cell motility and invasiveness. LOX activity is required during extravasation and/or initial tissue colonization by circulating MDA-MB-231 cells, metastasis model and drug administration study in mice, overview Homo sapiens