Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chapelsky, S.; Batty, S.; Frost, M.; Mogridge, J.
    Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol (2008), PLoS ONE, 3, e1421.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.24.83 molecular biology celastrol is identified as an inhibitor of lethal toxin-mediated macrophage lysis and suggests an inhibitory mechanism involving inhibition of the proteasome pathway Bacillus anthracis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.83 celastrol celastrol, a quinine methide triterpene derived from a plant extract used in herbal medicine, inhibits lethal toxin-induced death of RAW264.7 murine macrophages. Celastrol does not prevent cleavage of mitogen activated protein kinase kinase 1. Celastrol confers almost complete protection when it is added up to 1.5 h after intoxication, indicating that it can rescue cells in the late stages of intoxication. Celastrol inhibits the proteasome-dependent degradation of proteins in RAW264.7 cells. Celastrol blocks stimulation of IL-18 processing, indicating that celastrol acts upstream of inflammasome activation Bacillus anthracis

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.83 Bacillus anthracis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.83 mitogen activated protein kinase kinase 1 + H2O
-
 Bacillus anthracis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.83 anthrax lethal toxin
-
 Bacillus anthracis
3.4.24.83 LeTx
-
 Bacillus anthracis