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Literature summary extracted from

  • Abdulla, M.H.; OBrien, T.; Mackey, Z.B.; Sajid, M.; Grab, D.J.; McKerrow, J.H.
    RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model (2008), PLoS Negl. Trop. Dis., 2, e298.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.22.51 pharmacology induction of RNAi against brucipain of Trypanosoma brucei does not cure mice from infection, however, 50% of these mice survive 60 days longer than uninduced controls. The ability of Trypanosoma brucei to cross an in vitro model of the human blood-brain barrier is also reduced by brucipain RNAi induction Trypanosoma brucei

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.1 additional information suppression of cathepsin B by doxycyclin-induced RNAi results in parasite clearance from the bloodstream and prevents a lethal infection in mice causing African trypanosomiasis, overview Trypanosoma brucei
3.4.22.51 additional information induction of RNAi against brucipain of Trypanosoma brucei does not cure mice from infection, however, 50% of these mice survive 60 days longer than uninduced controls. The ability of Trypanosoma brucei to cross an in vitro model of the human blood-brain barrier is also reduced by brucipain RNAi induction Trypanosoma brucei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.1 additional information Trypanosoma brucei cathepsin B plays a key role in parasite infection, overview ?
-
 ?
3.4.22.1 additional information Trypanosoma brucei 90-13 cathepsin B plays a key role in parasite infection, overview ?
-
 ?
3.4.22.51 additional information Trypanosoma brucei enzyme may be involved in facilitating parasite entry into the brain ?
-
 ?
3.4.22.51 additional information Trypanosoma brucei 90-13 enzyme may be involved in facilitating parasite entry into the brain ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.1 Trypanosoma brucei
-
-
-
3.4.22.1 Trypanosoma brucei 90-13
-
-
-
3.4.22.51 Trypanosoma brucei
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.1 additional information cathepsin B plays a key role in parasite infection, overview Trypanosoma brucei ?
-
 ?
3.4.22.1 additional information cathepsin B plays a key role in parasite infection, overview Trypanosoma brucei 90-13 ?
-
 ?
3.4.22.51 additional information enzyme may be involved in facilitating parasite entry into the brain Trypanosoma brucei ?
-
 ?
3.4.22.51 additional information enzyme may be involved in facilitating parasite entry into the brain Trypanosoma brucei 90-13 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.1 CatB
-
 Trypanosoma brucei
3.4.22.51 brucipain
-
 Trypanosoma brucei