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Literature summary extracted from

  • Volfova, V.; Hostomska, J.; Cerny, M.; Votypka, J.; Volf, P.
    Hyaluronidase of bloodsucking insects and its enhancing effect on leishmania infection in mice (2008), PLoS Negl. Trop. Dis., 2, e294.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.2.1.35 medicine hyaluronidase promotes Leishmania establishment in murine skin Bos taurus

Protein Variants

EC Number Protein Variants Comment Organism
3.2.1.35 additional information the effect of hyaluronidase coinoculation on the outcome of Leishmania major infection in BALB/c mice: Hyaluronidase exacerbates skin lesions caused by Leishmania major, more severe lesions developed in mice where Leishmania major promastigotes are coinjected with hyaluronidase Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.1.35 35000
-
 SDS-PAGE under non-reducing conditions, major band at 35000 Da Culicoides kibunensis
3.2.1.35 40000
-
 SDS-PAGE under non-reducing conditions Eusimulium latipes
3.2.1.35 40000
-
 SDS-PAGE under non-reducing conditions Simulium ornatum
3.2.1.35 50000
-
 SDS-PAGE under non-reducing conditions Chrysops viduatus
3.2.1.35 52000
-
 SDS-PAGE under non-reducing conditions, three enzyme bands are detected the most prominent one at 52000 Da Ctenocephalides felis
3.2.1.35 70000
-
 SDS-PAGE under non-reducing conditions Phlebotomus papatasi
3.2.1.35 70000
-
 SDS-PAGE under non-reducing conditions, minor band at 70000 Da Culicoides kibunensis

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.35 Bos taurus
-
-
-
3.2.1.35 Chrysops viduatus
-
-
-
3.2.1.35 Ctenocephalides felis
-
-
-
3.2.1.35 Culex quinquefasciatus
-
-
-
3.2.1.35 Culicoides kibunensis
-
-
-
3.2.1.35 Eusimulium latipes
-
-
-
3.2.1.35 Phlebotomus papatasi
-
-
-
3.2.1.35 Simulium ornatum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.35 salivary gland
-
 Culex quinquefasciatus
-
3.2.1.35 salivary gland
-
 Phlebotomus papatasi
-
3.2.1.35 salivary gland
-
 Eusimulium latipes
-
3.2.1.35 salivary gland
-
 Chrysops viduatus
-
3.2.1.35 salivary gland
-
 Simulium ornatum
-
3.2.1.35 testis
-
 Bos taurus
-
3.2.1.35 whole body
-
 Ctenocephalides felis
-
3.2.1.35 whole body
-
 Culicoides kibunensis
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.2.1.35 additional information
-
 enzyme shows low enzymatic activity. Hyaluronan is the preferred substrate Ctenocephalides felis
3.2.1.35 additional information
-
 enzyme shows pronounced enzymatic activity Culex quinquefasciatus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.35 chondroitin sulfate + H2O
-
 Culex quinquefasciatus ?
-
 ?
3.2.1.35 chondroitin sulfate + H2O
-
 Ctenocephalides felis ?
-
 ?
3.2.1.35 chondroitin sulfate + H2O
-
 Phlebotomus papatasi ?
-
 ?
3.2.1.35 chondroitin sulfate + H2O
-
 Eusimulium latipes ?
-
 ?
3.2.1.35 chondroitin sulfate + H2O
-
 Chrysops viduatus ?
-
 ?
3.2.1.35 chondroitin sulfate + H2O
-
 Simulium ornatum ?
-
 ?
3.2.1.35 chondroitin sulfate + H2O
-
 Culicoides kibunensis ?
-
 ?
3.2.1.35 hyaluronan + H2O
-
 Culex quinquefasciatus ?
-
 ?
3.2.1.35 hyaluronan + H2O
-
 Ctenocephalides felis ?
-
 ?
3.2.1.35 hyaluronan + H2O
-
 Phlebotomus papatasi ?
-
 ?
3.2.1.35 hyaluronan + H2O
-
 Eusimulium latipes ?
-
 ?
3.2.1.35 hyaluronan + H2O
-
 Chrysops viduatus ?
-
 ?
3.2.1.35 hyaluronan + H2O
-
 Simulium ornatum ?
-
 ?
3.2.1.35 hyaluronan + H2O
-
 Culicoides kibunensis ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.2.1.35 dimer 2 * 35000, SDS-PAGE under non-reducing conditions Culicoides kibunensis

Synonyms

EC Number Synonyms Comment Organism
3.2.1.35 hyaluronidase
-
 Bos taurus
3.2.1.35 hyaluronidase
-
 Culex quinquefasciatus
3.2.1.35 hyaluronidase
-
 Ctenocephalides felis
3.2.1.35 hyaluronidase
-
 Phlebotomus papatasi
3.2.1.35 hyaluronidase
-
 Eusimulium latipes
3.2.1.35 hyaluronidase
-
 Chrysops viduatus
3.2.1.35 hyaluronidase
-
 Simulium ornatum
3.2.1.35 hyaluronidase
-
 Culicoides kibunensis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.35 37
-
 assay at Culex quinquefasciatus
3.2.1.35 37
-
 assay at Ctenocephalides felis
3.2.1.35 37
-
 assay at Phlebotomus papatasi
3.2.1.35 37
-
 assay at Eusimulium latipes
3.2.1.35 37
-
 assay at Chrysops viduatus
3.2.1.35 37
-
 assay at Simulium ornatum
3.2.1.35 37
-
 assay at Culicoides kibunensis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.35 5.5
-
 assay at Culex quinquefasciatus
3.2.1.35 5.5
-
 assay at Ctenocephalides felis
3.2.1.35 5.5
-
 assay at Phlebotomus papatasi
3.2.1.35 5.5
-
 assay at Eusimulium latipes
3.2.1.35 5.5
-
 assay at Chrysops viduatus
3.2.1.35 5.5
-
 assay at Simulium ornatum
3.2.1.35 5.5
-
 assay at Culicoides kibunensis