EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.34 | squalestatin | leads to a significant concentration-dependent activation of HMGR of ca. 3fold the activity in untreated plants. Maximal HMGR activation at 0.06 mM squalestatin. No relevant changes in the level of expression of the HMG genes or in the amount of HMGR protein | Arabidopsis thaliana | |
1.1.1.34 | terbinafine | leads to a significant concentration-dependent activation of HMGR of ca. 3fold the activity in untreated plants. Maximal HMGR activation at 0.75 mM terbinafine. No relevant changes in the level of expression of the HMG genes or in the amount of HMGR protein | Arabidopsis thaliana |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.34 | additional information | whether plants are grown with mevalonate from the beginning or only during the last 9 days, HMGR activity is drastically reduced to 25% of the activity in plants grown in the absence of mevalonate. Plants grown without mevalonate during the last 9 days show a severe, though less pronounced, reduction in HMGR activity, which decreases to 60% of the activity in control plants. Significant reduction of HMGR activity does not correlate with changes in both the expression of HMG1 and HMG2 genes and the amount of HMGR protein | Arabidopsis thaliana | |
1.1.1.34 | myriocin | concomitant reduction of both HMGR activity and the sterol content by depletion of the sphingolipid pathway. At 0.01 mM myriocin decrease to ca. 55% of the HMGR activity in control plants. Myriocin-induced down-regulation of HMGR activity is exerted at the post-translational level, like the regulatory response of HMGR to enhancement or depletion of the flux through the sterol pathway | Arabidopsis thaliana |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.34 | 63000 | - |
immunoblot analysis, isoform HMGR1S | Arabidopsis thaliana |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | Arabidopsis thaliana | up- and down-regulation of HMGR activity in response to changes in the flux of the mevalonate pathway occur via post-translational control | mevalonate + CoA + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.34 | Arabidopsis thaliana | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | up- and down-regulation of HMGR activity in response to changes in the flux of the mevalonate pathway occur via post-translational control | Arabidopsis thaliana | mevalonate + CoA + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.34 | HMG1 | - |
Arabidopsis thaliana |
1.1.1.34 | HMG2 | - |
Arabidopsis thaliana |
1.1.1.34 | HMGR | - |
Arabidopsis thaliana |