Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Li, S.H.; Li, G.; Huang, H.M.; Xiong, F.; Mai, X.; Kuang, B.H.; Liu, C.M.; Tu, G.G.
    Synthesis of 1,3,4-thiadiazole derivatives as aminopeptidase N inhibitors (2009), Pharmazie, 64, 67-70.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 (2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)-amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
-
 Homo sapiens
3.4.11.2 (2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
 Homo sapiens
3.4.11.2 bestatin
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.2 Zn2+ dependent on Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 L-Leu-p-nitroanilide + H2O
-
 Homo sapiens L-Leu + p-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.2 aminopeptidase N
-
 Homo sapiens
3.4.11.2 APN
-
 Homo sapiens
3.4.11.2 CD13
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.11.2 0.0085
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens bestatin
3.4.11.2 0.0399
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
3.4.11.2 0.0488
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
3.4.11.2 0.0698
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
3.4.11.2 0.0964
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
3.4.11.2 0.107
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
3.4.11.2 0.1073
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
3.4.11.2 0.1153
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
3.4.11.2 0.1178
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
3.4.11.2 0.1416
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
3.4.11.2 0.1678
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
3.4.11.2 0.169
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
3.4.11.2 0.1701
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)-amino]-propanamide
3.4.11.2 0.1905
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
3.4.11.2 0.2058
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
3.4.11.2 0.2875
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
3.4.11.2 0.2966
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
3.4.11.2 0.3089
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
3.4.11.2 0.3091
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
3.4.11.2 0.3178
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
3.4.11.2 0.3378
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
3.4.11.2 0.3732
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide