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Literature summary extracted from

  • Labrie, V.; Clapcote, S.J.; Roder, J.C.
    Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors (2009), Pharmacol. Biochem. Behav., 91, 610-620.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.4.3.3 D481N homozygous Grin1D481N mutant mice with reduced NMDA-NR1 glycine affinity exhibit an altered anxiety-like behavior. Deficient DAO activity also reverses the anxiolytic effects of diminished NMDAR function in mice carrying both the homozygous Grin1D481N and Dao1G181R mutation, phenotypes, overview Mus musculus
1.4.3.3 G181R homozygous Dao1G181R mutant mice that lack function of the D-serine catabolic enzyme DAO display an elevation in anxiety, homozygous Grin1D481N mutant mice with reduced NMDA-NR1 glycine affinity exhibit also an altered anxiety-like behavior. Deficient DAO activity also reverses the anxiolytic effects of diminished NMDAR function in mice carrying both the homozygous Grin1D481N and Dao1G181R mutation, phenotypes, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.3 D-serine + H2O + O2 Mus musculus physiological effects of D-serine, overview 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2 Mus musculus C57/BL6J physiological effects of D-serine, overview 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Mus musculus
-
 C57BL/6J mice
-
1.4.3.3 Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-serine + H2O + O2
-
 Mus musculus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2 physiological effects of D-serine, overview Mus musculus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2
-
 Mus musculus C57/BL6J 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2 physiological effects of D-serine, overview Mus musculus C57/BL6J 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 DAO
-
 Mus musculus