Literature summary extracted from

Rosenstock, T.R.; Abilio, V.C.; Frussa-Filho, R.; Kiyomoto, B.H.; Smaili, S.S.
Old mice present increased levels of succinate dehydrogenase activity and lower vulnerability to dyskinetic effects of 3-nitropropionic acid (2009), Pharmacol. Biochem. Behav., 91, 327-332.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.3.5.1	3-nitropropionic acid	this study compares the effects of 3-nitropropionic acid in young and old mice. Treatment with 3-nitropropionic acid induces OD in young mice. Old mice present an increase in the basal level of orofacial movement that is not potentiated by any dose of 3-nitropropionic acid. Histochemical analyses show that old mice present an increase in the SDH activity. 3-Nitropropionic acid induces a decrease in SDH activity at both ages	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.3.5.1	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.3.5.1	brain	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.3.5.1	succinate + oxidized donor	endogenous SDH activity results in blue diphormazan deposits from the nitroblue tetrazolium reduction through succinate oxidation	Mus musculus	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.3.5.1	SDH	-	Mus musculus
1.3.5.1	succinate dehydrogenase	-	Mus musculus

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
1.3.5.1	37	-	assay at	Mus musculus

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
1.3.5.1	7.4	-	assay at	Mus musculus

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Release 2023.1 (January 2023)